2',3',5'-三-O-乙酰-6-氯-2-碘嘌呤核苷合成路线 （共 15 条）
反应条件
diiodomethane; iodine; isopentyl nitrite; copper(l) iodide in tetrahydrofuran 0.75 h; Heating;
参考文献
Gruenewald, Christian; Kwon, Taewoo; Piton, Nelly; Foerster, Ute; Wachtveitl, Josef; Engels, Joachim W.
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 1 p. 19 - 26
反应条件
copper(l) iodide; diiodomethane; iodine; isopentyl nitrite in tetrahydrofuran 0.75 h; Heating;
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 2 p. 241 - 252
反应条件
I2; CuI; iodine in tetrahydrofuran
参考文献
US6232297 B1, ;
US 6232297 B1
反应条件
1: POCl3; N,N-diethylaniline 2: n-C5H11ONO; CH2I2 / acetonitrile View Scheme
参考文献
Nucleosides, Nucleotides and Nucleic Acids, , vol. 24, # 5-7 p. 717 - 720
反应条件
copper(l) iodide; diiodomethane; iodine; isopentyl nitrite T=80°C; 0.25 h;
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 2 p. 241 - 252
反应条件
1: DMAP; Et3N / acetonitrile 2: POCl3; N,N-diethylaniline 3: n-C5H11ONO; CH2I2 / acetonitrile View Scheme
参考文献
Nucleosides, Nucleotides and Nucleic Acids, , vol. 24, # 5-7 p. 717 - 720
反应条件
diiodomethane; isopentyl nitrite T=80°C; 0.416667 h; Heating;
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 2 p. 241 - 252
反应条件
1: 89 percent / pyridine / dimethylformamide / 2 h / 80 °C 2: 69 percent / t-butyl nitrite; CH2I2 / acetonitrile / 3 h / 80 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 12, # 11 p. 2995 - 3007
反应条件
ammonia in ethanol T=25°C; 23 h;
参考文献
Nair; Young
Journal of Organic Chemistry, 1985 , vol. 50, # 3 p. 406 - 408
反应条件
1: 92 percent / CuI, (PPh3)2PdCl2, Et3N / dioxane / 1 h / Ambient temperature 2: 300 mg / conc. NH4OH / dioxane / 20 h / 70 °C View Scheme
参考文献
Abiru; Miyashita; Watanabe; Yamaguchi; Machida; Matsuda
Journal of Medicinal Chemistry, 1992 , vol. 35, # 12 p. 2253 - 2260
