2,3,5-三-O-乙酰基-6-氯嘌呤-9-β-D-呋喃核糖苷合成路线 （共 37 条）
反应条件
1: triethylamine / ethanol; dichloromethane / 20 - 60 °C 2: methanol; ammonia / 3 h View Scheme
参考文献
Anglin, Justin L.; Deng, Lisheng; Yao, Yuan; Cai, Guobin; Liu, Zhen; Jiang, Hong; Cheng, Gang; Chen, Pinhong; Song, Yongcheng; Dong, Shuo
Journal of Medicinal Chemistry, 2012 , vol. 55, # 18 p. 8066 - 8074,9
反应条件
in ethanol; water T=20°C; 12 h;
参考文献
Hoebartner, Claudia; Kreutz, Christoph; Flecker, Elke; Ottenschlaeger, Elke; Pils, Werner; Grubmayr, Karl; Micura, Ronald
Monatshefte fur Chemie, 2003 , vol. 134, # 6 p. 851 - 873
反应条件
ammonia in methanol T=-20 - 0°C;
参考文献
Mathew, Smitha C.; Ghosh, Nandita; By, Youlet; Berthault, Aurelie; Virolleaud, Marie-Alice; Carrega, Louis; Chouraqui, Gaelle; Commeiras, Laurent; Condo, Jocelyne; Attolini, Mireille; Gaudel-Siri, Anouk; Ruf, Jean; Parrain, Jean-Luc; Rodriguez, Jean; Guieu, Regis
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 23 p. 6736 - 6739
反应条件
1: 67.3 percent / H2 / MgO / 10percent Pd-C / methanol / 4 h / Ambient temperature 2: 76 percent / NH3 / methanol / 30 h / 0 °C View Scheme
参考文献
Gupta, P. K.; Bhakuni, D. S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1981 , vol. 20, # 7 p. 534 - 537
反应条件
1: ammonia / methanol 2: triethylamine / ethanol / 24 h / 78 °C View Scheme
参考文献
Anglin, Justin L.; Deng, Lisheng; Yao, Yuan; Cai, Guobin; Liu, Zhen; Jiang, Hong; Cheng, Gang; Chen, Pinhong; Song, Yongcheng; Dong, Shuo
Journal of Medicinal Chemistry, 2012 , vol. 55, # 18 p. 8066 - 8074,9
反应条件
hydrogen; sodium acetate; palladium on activated charcoal in methanol P=2068.6 Torr; 24 h; Ambient temperature;
参考文献
Buffel, Diederik K.; McGuigan, Christopher; Robins, Morris J.
Journal of Organic Chemistry, 1985 , vol. 50, # 15 p. 2664 - 2667
反应条件
1: 71 percent / tetrabutylammonium nitrate (TBAN); trifluoroacetic anhydride (TFAA) / CH2Cl2 / 2.5 h / 0 °C 2: NaN3 / dimethylformamide 4: HOAc / H2O 5: 68 percent / KCN / methanol 6: 80 percent / H2 / Raney Ni View Scheme
参考文献
Deghati, Paymaneh Y. F.; Wanner, Martin J.; Koomen, Gerrit-Jan
Tetrahedron Letters, 2000 , vol. 41, # 8 p. 1291 - 1295
反应条件
1: ammonia / methanol 2: triethylamine / ethanol / 24 h / 78 °C View Scheme
参考文献
Anglin, Justin L.; Deng, Lisheng; Yao, Yuan; Cai, Guobin; Liu, Zhen; Jiang, Hong; Cheng, Gang; Chen, Pinhong; Song, Yongcheng; Dong, Shuo
Journal of Medicinal Chemistry, 2012 , vol. 55, # 18 p. 8066 - 8074,9
反应条件
1.1: 51 percent / NaOMe / methanol 2.1: dimethylformamide / 0 °C 2.2: 42 percent / Et3N / dimethylformamide / 0 °C View Scheme
参考文献
Patching, Simon G.; Baldwin, Stephen A.; Baldwin, Alexander D.; Young, James D.; Gallagher, Maurice P.; Henderson, Peter J. F.; Herbert, Richard B.
Organic and Biomolecular Chemistry, 2005 , vol. 3, # 3 p. 462 - 470
反应条件
in ethanol; water T=20°C; 9 h;
参考文献
Hoebartner, Claudia; Kreutz, Christoph; Flecker, Elke; Ottenschlaeger, Elke; Pils, Werner; Grubmayr, Karl; Micura, Ronald
Monatshefte fur Chemie, 2003 , vol. 134, # 6 p. 851 - 873
