1.1: NaH / dimethylformamide / 0 °C 1.2: 75 percent / dimethylformamide / 0 - 20 °C 2.1: BH3*THF; (S)-proline (R)-1,1'-bi(2-naphthyl)dioxyboryl ester / tetrahydrofuran / 48 h / 0 - 5 °C 2.2: aq. HCl / tetrahydrofuran View Scheme

zeolyte H-Y supported KMnO4 in 1,2-dichloro-ethane 0.5 h; Ambient temperature;

1-propanephosphonic acid cyclic anhydride in tetrahydrofuran; ethyl acetate T=70°C; Beckmann rearrangement; 3 h; Inert atmosphere;

1.1: NaH / dimethylformamide / 0 °C 1.2: 75 percent / dimethylformamide / 0 - 20 °C 2.1: BH3*THF; (S)-proline (R)-1,1'-bi(2-naphthyl)dioxyboryl ester / tetrahydrofuran / 48 h / 0 - 5 °C 2.2: aq. HCl / tetrahydrofuran View Scheme