4-羟基间苯二甲酸二甲酯合成路线 （共 33 条）
反应条件
1: 4-hydroxy-isophthalonitrile With sulfuric acid; water T=135°C; 13 h; 2: methanol T=95°C; 1.5 h;
参考文献
COMENTIS, INC.; BILCER, Geoffrey, M.; LILLY, John, C.; SWANSON, Lisa, M.
Patent: WO2011/130383 A1, 2011 ;
Location in patent: Page/Page column 95-96 ;
WO 2011/130383 A1
反应条件
sulfuric acid in methanol
参考文献
Chemische Berichte, , vol. 11, p. 374
Chemische Berichte, , vol. 25, p. 2797
反应条件
potassium tert-butylate in toluene 3 h; Ambient temperature;
参考文献
Anke; Schramm; Schwalge; et al.
1984 , vol. 1984, # 9 p. 1616 - 1625
参考文献
Journal of the American Chemical Society, , vol. 72, p. 1982,1983
反应条件
1: NaOMe / methanol 2: HCl View Scheme
参考文献
J. Gen. Chem. USSR (Engl. Transl.), , vol. 35, p. 1952 - 1955,1944 - 1947
反应条件
1: NaOCH2nBu / pentan-1-ol 2: HCl View Scheme
参考文献
J. Gen. Chem. USSR (Engl. Transl.), , vol. 35, p. 1952 - 1955,1944 - 1947
反应条件
1.1: dimethyl sulfoxide / 2 h / 100 °C 1.2: pH 1 - 2 2.1: water; sulfuric acid / 13 h / 135 °C 2.2: 1.5 h / 95 °C View Scheme
参考文献
WO2011/130383 A1, ;
WO 2011/130383 A1
反应条件
magnesium methanolate in chloroform 96 h; Ambient temperature; Yield given;
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 14 p. 1695 - 1698
反应条件
magnesium in chloroform 96 h; Ambient temperature; Yield given;
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 14 p. 1695 - 1698
