四氢-4-亚甲基-2-(2-甲基丙基)-2H-吡喃合成路线 （共 6 条）
反应条件
1: With 18-crown-6 ether; potassium hydride in diethyl ether; dichloromethane
T=25°C; Addition; 2 h;
2: With tetrabutylammonium hexanitratocerate(IV); 4 Angstroem MS in dichloromethane; acetonitrile
T=-23 - 25°C; Cyclization; oxidation; 12 h; Further stages.;
参考文献
Chen, Chuanfeng; Mariano, Patrick S.
Journal of Organic Chemistry, 2000 , vol. 65, # 10 p. 3252 - 3254
反应条件
zinc in ethanol
T=70 - 80°C; further dehalogenation agent; Title compound not separated from byproducts;
参考文献
Kazaryan, P. I.; Avakyan, O. V.; Avakyan, S. V.; Gevorkyan, A. A.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1985 , vol. 21, # 9 p. 988 - 992
Khimiya Geterotsiklicheskikh Soedinenii, 1985 , vol. 21, # 9 p. 1189 - 1193
反应条件
sulfuric acid
T=25°C;
参考文献
Margot, Christian; Rizzolio, Michele; Schlosser, Manfred
Tetrahedron, 1990 , vol. 46, # 7 p. 2411 - 2424
反应条件
1: 60 percent / KBr / benzene; aq. HBr / 2 h / 0 °C
2: 81 percent / CHCl3; HCl / 5 h / 0 °C
3: Zn / ethanol / 70 - 80 °C / further dehalogenation agent
View Scheme
参考文献
Kazaryan, P. I.; Avakyan, O. V.; Avakyan, S. V.; Gevorkyan, A. A.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1985 , vol. 21, # 9 p. 988 - 992
Khimiya Geterotsiklicheskikh Soedinenii, 1985 , vol. 21, # 9 p. 1189 - 1193
反应条件
1: 81 percent / CHCl3; HCl / 5 h / 0 °C
2: Zn / ethanol / 70 - 80 °C / further dehalogenation agent
View Scheme
参考文献
Kazaryan, P. I.; Avakyan, O. V.; Avakyan, S. V.; Gevorkyan, A. A.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1985 , vol. 21, # 9 p. 988 - 992
Khimiya Geterotsiklicheskikh Soedinenii, 1985 , vol. 21, # 9 p. 1189 - 1193
反应条件
aluminum oxide
T=20°C; 20 h;
参考文献
Ibatullin, U. G.; Pavlov, Yu. V.; Safarov, M. G.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1989 , vol. 25, # 10 p. 1107 - 1109
Khimiya Geterotsiklicheskikh Soedinenii, 1989 , # 10 p. 1326 - 1328
