3-(3-硝基苯基)-1H-吡唑合成路线 （共 10 条）
反应条件
in N,N-dimethyl-formamide
参考文献
Glaxo Wellcome Inc.
Patent: US5866612 A1, 1999 ;
反应条件
(isomerization) in cyclohexane T=25°C; Rate constant;
参考文献
Journal of the American Chemical Society, , vol. 91, # 3 p. 711 - 715
反应条件
trichlorophosphate T=40 - 80°C; Vilsmeier formylation;
参考文献
Russian Journal of General Chemistry, , vol. 75, # 5 p. 782 - 789
反应条件
1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 1,4-dioxane / 2 h / 20 °C / Inert atmosphere 2: hydrazine monohydrochloride; water; toluene-4-sulfonic acid / 1,4-dioxane / 0.25 h / 80 °C / Inert atmosphere View Scheme
参考文献
Molecules, , vol. 16, # 11 p. 9340 - 9356
反应条件
hydrazine in water T=25°C; Kinetics;
参考文献
Journal of Organic Chemistry, , vol. 70, # 19 p. 7530 - 7536
反应条件
1.1: AcONa / ethanol / 0.75 h / Heating 1.2: ethanol / 1 h / Heating 2.1: 3 percent / POCl3 / 40 - 80 °C View Scheme
参考文献
Russian Journal of General Chemistry, , vol. 75, # 5 p. 782 - 789
反应条件
copper(l) iodide; [Pd(PPh3)2(OAc)2]; potassium tert-butylate; triethylamine; palladium dichloride 1.) THF, room temp., 1.25 h, 2.) MeCN, reflux, 3.5 h, 3.) DMF, room temp., 2.25 h; Yield given. Multistep reaction;
参考文献
Synlett, , vol. 1997, # 8 p. 959 - 961
反应条件
diethyl ether; hydrazine hydrate
参考文献
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, , p. 1181,1185; engl. Ausg. S. 1206, 1209
反应条件
1: AlCl3 2: diethyl ether; N2H4+H2O View Scheme
参考文献
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, , p. 1181,1185; engl. Ausg. S. 1206, 1209
反应条件
hydrogen; palladium 10 on activated carbon in methanol T=20°C;
参考文献
AMGEN INC.; DU, Xiaohui; FU, Zice; HOUZE, Jonathan, B.; JIAO, Xianyun; KIM, Yong-jae; LI, Leping; LIU, Jinqian; LIZARZABURU, Mike; MEDINA, Julio; SHEN, Wang; TURCOTTE, Simon; YU, Ming
Patent: WO2010/93849 A2, 2010 ;
Location in patent: Page/Page column 58 ;
WO 2010/093849 A2
