N-Cbz-L-苯丙氨醛合成路线 （共 29 条）
反应条件
1: H2 / Pd/C 2: 23 °C 3: 85 percent / NaBH4 / 120 h / 23 °C View Scheme
参考文献
Myers, Andrew G.; Kung, Daniel W.; Zhong, Boyu
Journal of the American Chemical Society, 2000 , vol. 122, # 13 p. 3236 - 3237
反应条件
ammonium hydroxide; iodine in tetrahydrofuran T=25°C;
参考文献
Shie, Jiun-Jie; Fang, Jim-Min
Journal of Organic Chemistry, 2007 , vol. 72, # 8 p. 3141 - 3144
反应条件
sodium tetrahydroborate in ethanol
参考文献
Miyazaki, Tohru; Han-Ya, Yuki; Tokuyama, Hidetoshi; Fukuyama, Tohru
Synlett, 2004 , # 3 p. 477 - 480
反应条件
lithium diisopropyl amide
1.) THF, -40 deg C 2.) - 40 to 25 deg C, 2 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Nakamura, Eiichi
Tetrahedron Letters, 1981 , vol. 22, p. 663 - 666
反应条件
1: aq. NaOH/aq. H2O2 / ethanol / 0.33 h / 65 °C
2: 99 percent / DCC / CH2Cl2 / 10 h / Ambient temperature
3: 99 percent / Jones' reagent
View Scheme
参考文献
Kashima, Choji; Harada, Kazuo; Fujioka, Yoko; Maruyama, Tatsuya; Omote, Yoshimori
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 535 - 540
反应条件
1: NaH / tetrahydrofuran / 0 °C
2: I2 / acetonitrile / Ambient temperature
3: 85 percent / n-Bu3SnH / toluene / Heating
4: alkaline hydrolysis
View Scheme
参考文献
Misiti; Zappia
Tetrahedron Letters, 1990 , vol. 31, # 50 p. 7359 - 7362
反应条件
in tetrahydrofuran
15 h; Ambient temperature;
参考文献
Kashima, Choji; Maruyama, Tatsuya; Fujioka, Yoko; Harada, Kazuo
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1989 , p. 1041 - 1046
反应条件
1: 95 percent / p-toluenesulphonic acid / CH2Cl2 / Heating
2: BF3*Et2O / CH2Cl2 / 2 h / Ambient temperature
3: 1.) pyridinium chlorochromate; 2.) HCl / 2.) Et2O, 4 deg C, 24 h
4: NaOH / dioxane; H2O
View Scheme
参考文献
Herranz, Rosario; Castro-Pichel, Julia; Garcia-Lopez, Teresa
Synthesis, 1989 , # 9 p. 703 - 706
反应条件
1: aq. NaOH/aq. H2O2 / ethanol / 0.33 h / 65 °C
2: 99 percent / DCC / CH2Cl2 / 10 h / Ambient temperature
3: 99 percent / Jones' reagent
4: 35 percent / DCC
5: 80 percent / Jones' reagent
View Scheme
参考文献
Kashima, Choji; Harada, Kazuo; Fujioka, Yoko; Maruyama, Tatsuya; Omote, Yoshimori
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 535 - 540
