[1,1-联苯]-4-乙酸甲酯合成路线 (共 21 条)
反应条件
lithium aluminium tetrahydride in diethyl ether T=0°C;
参考文献
Grolla, Ambra A.; Podesta, Valeria; Chini, Maria Giovanna; Di Micco, Simone; Vallario, Antonella; Genazzani, Armando A.; Canonico, Pier Luigi; Bifulco, Giuseppe; Tron, Gian Cesare; Sorba, Giovanni; Pirali, Tracey
Journal of Medicinal Chemistry, 2009 , vol. 52, # 9 p. 2776 - 2785
反应条件
sodium hydroxide in methanol 4 h; Ambient temperature; Yield given;
参考文献
Giordano, Claudio; Castaldi, Graziano; Casagrande, Francesco; Belli, Aldo
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , # 11 p. 2575 - 2582
反应条件
hydrogenchloride in methanol; ethyl acetate; Petroleum ether
参考文献
Boehringer Ingelheim Pharmaceuticals, Inc.
Patent: US6054470 A1, 2000 ;
US 6054470 A
反应条件
TEA; (2-chloro-1-pyridinio)-(Wang resin) triflate in dichloromethane
0.25 h;
参考文献
Sugiyama, Yuya; Kurata, Yuki; Kunda, Yoko; Miyazaki, Atsushi; Matsui, Junko; Nakamura, Shuichi; Hamamoto, Hiromi; Shioiri, Takayuki; Matsugi, Masato
Tetrahedron, 2012 , vol. 68, # 20 p. 3885 - 3892
反应条件
cesium fluoride; tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether
2 h; Heating;
参考文献
Wright, Stephen W.; Hageman, David L.; McClure, Lester D.
Journal of Organic Chemistry, 1994 , vol. 59, # 20 p. 6095 - 6097
反应条件
toluene-4-sulfonic acid in methanol
4 h; RefluxInert atmosphere;
参考文献
Abdu-Allah, Hajjaj H. M.; Tamanaka, Taichi; Yu, Jie; Zhuoyuan, Lu; Sadagopan, Magesh; Adachi, Takahiro; Tsubata, Takeshi; Kelm, Soerge; Ishida, Hideharu; Kiso, Makoto
Journal of Medicinal Chemistry, 2008 , vol. 51, # 21 p. 6665 - 6681
反应条件
cesium fluoride; tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether
18 h; Heating;
参考文献
Wright, Stephen W.; Hageman, David L.; McClure, Lester D.
Journal of Organic Chemistry, 1994 , vol. 59, # 20 p. 6095 - 6097
反应条件
potassium carbonate in N-methyl-acetamide
参考文献
SmithKline Beecham p.l.c.
Patent: US6048852 A1, 2000 ;
US 6048852 A
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene
4 h; Cooling with ice;
参考文献
Wang, Jin; Burdzinski, Gotard; Kubicki, Jacek; Platz, Matthew S.
Journal of the American Chemical Society, 2008 , vol. 130, # 33 p. 11195 - 11209
反应条件
sulfuric acid; trimethyl orthoformate
T=20°C; 0.333333 h;
参考文献
Justik, Michael W.
Tetrahedron Letters, 2007 , vol. 48, # 17 p. 3003 - 3007