4-溴-2-氯苯甲酸合成路线

59748-90-24-溴-2-氯苯甲酸→67197-54-02-氯-4-溴苯基乙腈

参考文献

AFRAXIS, INC.; CAMPBELL, David; DURÓN, Sergio, G.
Patent: WO2013/43232 A2, 2013 ;
WO 2013/043232 A2

参考文献

Fevig, John M.; Feng, Jianxin; Rossi, Karen A.; Miller, Keith J.; Wu, Ginger; Hung, Chen-Pin; Ung, Thao; Malmstrom, Sarah E.; Zhang, Ge; Keim, William J.; Cullen, Mary Jane; Rohrbach, Kenneth W.; Qu, Qinling; Gan, Jinping; Pelleymounter, Mary Ann; Robl, Jeffrey A.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 1 p. 330 - 335

59748-90-24-溴-2-氯苯甲酸→86611-61-2

参考文献

Stewart, Georgina M.; Rewcastle, Gordon W.; Denny, William A.
Australian Journal of Chemistry, 1984 , vol. 37, # 9 p. 1939 - 1950

59748-90-24-溴-2-氯苯甲酸→86611-62-3

参考文献

Stewart, Georgina M.; Rewcastle, Gordon W.; Denny, William A.
Australian Journal of Chemistry, 1984 , vol. 37, # 9 p. 1939 - 1950

59748-90-24-溴-2-氯苯甲酸+172975-69-83,5-二甲基苯硼酸→884323-17-53-氯-3,5-二甲基-[1,1-联苯]-4-羧酸

参考文献

Mei, Xuefeng; Wolf, Christian
Journal of the American Chemical Society, 2006 , vol. 128, # 41 p. 13326 - 13327

59748-90-24-溴-2-氯苯甲酸→884323-18-6

参考文献

Mei, Xuefeng; Martin, Rhia M.; Wolf, Christian
Journal of Organic Chemistry, 2006 , vol. 71, # 7 p. 2854 - 2861

59748-90-24-溴-2-氯苯甲酸+73183-34-3联硼酸频那醇酯→890839-31-34-羧基-3-氯苯硼酸频那醇酯

参考文献

SMITHKLINE BEECHAM CORPORATION
Patent: WO2006/63167 A1, 2006 ;
Location in patent: Page/Page column 31 ;
WO 2006/063167 A1

59748-90-24-溴-2-氯苯甲酸→908248-02-23-氯-4-甲酰基苯甲酸乙酯

参考文献

Zimmerman, Sommer S.; Khatri, Alpa; Garnier-Amblard, Ethel C.; Mullasseril, Praseeda; Kurtkaya, Natalie L.; Gyoneva, Stefka; Hansen, Kasper B.; Traynelis, Stephen F.; Liotta, Dennis C.
Journal of Medicinal Chemistry, 2014 , vol. 57, # 6 p. 2334 - 2356

24424-99-5二碳酸二叔丁酯+59748-90-24-溴-2-氯苯甲酸→929000-18-04-溴-2-氯苯甲酸叔丁酯

参考文献

Hunter, James E.; Lo, William C.; Watson, Gerald B.; Patny, Akshay; Gustafson, Gary D.; Pernich, Dan; Brewster, William K.; Camper, Debra L.; Lorsbach, Beth; Loso, Michael R.; Sparks, Thomas C.; Joshi, Hemant; Mandaleswaran, Adiraj; Sanam, Ramadevi; Gundla, Rambabu; Iyer, Pravin S.
Patent: US2012/329649 A1, 2012 ;
Location in patent: Page/Page column 27 ;

59748-90-24-溴-2-氯苯甲酸+118-92-3邻氨基苯甲酸→94636-83-6

参考文献

Denny; Atwell; Baguley
Journal of Medicinal Chemistry, 1983 , vol. 26, # 11 p. 1619 - 1625