反应条件
1: 4-methyl-morpholine / tetrahydrofuran / 0.17 h / -15 °C 2: sodium tetrahydroborate; water / tetrahydrofuran / 1 h / -5 - 0 °C 3: phosphorus tribromide / 1,2-dichloro-ethane / 0.67 h / 0 - 10 °C View Scheme
参考文献
GLAXOSMITHKLINE LLC; ADAMS, Nicholas, David; CHAUDHARI, Amita, M.; KIESOW, Terence, John; McSHERRY, Allison, K.; MOORE, Michael, Lee; PARRISH, Cynthia, Ann; REIF, Alexander, Joseph; RIDGERS, Lance, Howard
Patent: WO2014/8223 A2, 2014 ;