2’,3’-二脱氢-2’,3’-二脱氧尿苷合成路线 （共 55 条）
反应条件
1: NaH / N,N-dimethyl-acetamide / 0.5 h / 100 °C
2: TFA, pyrrole / CH2Cl2 / 10 h / Ambient temperature
3: 76 percent / tri-n-butyltin hydride, azobis-isobutyronitrile / dioxane / Heating
View Scheme
参考文献
Johnson, Richard; Joshi, Bhalchandra V.; Neidle, Stephen; Reese, Colin B.; Snook, Chris F.
Tetrahedron Letters, 1992 , vol. 33, # 52 p. 8151 - 8154
反应条件
1: NaH / N,N-dimethyl-acetamide / 100 °C
2: TFA, pyrrole / CH2Cl2 / 10 h / Ambient temperature
3: 76 percent / tri-n-butyltin hydride, azobis-isobutyronitrile / dioxane / Heating
View Scheme
参考文献
Johnson, Richard; Joshi, Bhalchandra V.; Neidle, Stephen; Reese, Colin B.; Snook, Chris F.
Tetrahedron Letters, 1992 , vol. 33, # 52 p. 8151 - 8154
反应条件
1: pyridine / 1 h / 100 °C
2: pyridine / Ambient temperature
3: NaH / N,N-dimethyl-acetamide / 100 °C
4: TFA, pyrrole / CH2Cl2 / 10 h / Ambient temperature
5: 76 percent / tri-n-butyltin hydride, azobis-isobutyronitrile / dioxane / Heating
View Scheme
参考文献
Johnson, Richard; Joshi, Bhalchandra V.; Neidle, Stephen; Reese, Colin B.; Snook, Chris F.
Tetrahedron Letters, 1992 , vol. 33, # 52 p. 8151 - 8154
反应条件
1: pyridine / 1 h / 100 °C
2: pyridine / Ambient temperature
3: NaH / N,N-dimethyl-acetamide / 0.5 h / 100 °C
4: TFA, pyrrole / CH2Cl2 / 10 h / Ambient temperature
5: 76 percent / tri-n-butyltin hydride, azobis-isobutyronitrile / dioxane / Heating
View Scheme
参考文献
Johnson, Richard; Joshi, Bhalchandra V.; Neidle, Stephen; Reese, Colin B.; Snook, Chris F.
Tetrahedron Letters, 1992 , vol. 33, # 52 p. 8151 - 8154
反应条件
1: 88 percent / acetonitrile / Heating
2: 63 percent / Zn/Cu / dimethylformamide / Ambient temperature
3: 88 percent / NH3 / methanol / Ambient temperature
View Scheme
参考文献
Talekar; Coe; Walker
Synthesis, 1993 , # 3 p. 303 - 306
反应条件
1: 90 percent / tributhylstannane, azobis(isobutyronitrile) / benzene / 2 h / Heating
2: 93 percent / sodium methylate (0.1M) / methanol / Ambient temperature
View Scheme
参考文献
David, Serge; Sennyey, Gerard de
Carbohydrate Research, 1980 , vol. 82, p. 45 - 50
反应条件
1: 1.) tetrachloromethane, triethyl phosphate, triphenylphosphine; 2.) tributylstannane, azobis(isobutyronitrile) / 1.) 5 h, reflux; 2.) benzene, 2 h, reflux
2: 93 percent / sodium methylate (0.1M) / methanol / Ambient temperature
View Scheme
参考文献
David, Serge; Sennyey, Gerard de
Carbohydrate Research, 1980 , vol. 82, p. 45 - 50
反应条件
1: 64 percent / triphenylphosphine, triethyl phosphate, tetrachloromethane / 4 h / 80 °C
2: 90 percent / tributhylstannane, azobis(isobutyronitrile) / benzene / 2 h / Heating
3: 93 percent / sodium methylate (0.1M) / methanol / Ambient temperature
View Scheme
参考文献
David, Serge; Sennyey, Gerard de
Carbohydrate Research, 1980 , vol. 82, p. 45 - 50
反应条件
1: 34 percent / triphenylphosphine, triethyl phosphate, tetrachloromethane / 5 h / Heating
2: 1.) tetrachloromethane, triethyl phosphate, triphenylphosphine; 2.) tributylstannane, azobis(isobutyronitrile) / 1.) 5 h, reflux; 2.) benzene, 2 h, reflux
3: 93 percent / sodium methylate (0.1M) / methanol / Ambient temperature
View Scheme
参考文献
David, Serge; Sennyey, Gerard de
Carbohydrate Research, 1980 , vol. 82, p. 45 - 50
反应条件
1: 47 percent / disodium hydrogenphosphate, sodium amalgam / methanol / 3 h / -78 °C
2: 95 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 1.5 h / Ambient temperature
View Scheme
参考文献
Niihata; Kuno; Ebata; Matsushita
Bulletin of the Chemical Society of Japan, 1995 , vol. 68, # 8 p. 2327 - 2329
