2’,3’-二脱氢-2’,3’-二脱氧尿苷合成路线 （共 55 条）
反应条件
sodium hydride in N,N-dimethyl acetamide
T=100°C; 0.5 h;
参考文献
Joshi, Bhalchandra V.; Rao, T. Sudhakar; Reese, Colin B.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 19 p. 2537 - 2544
反应条件
2,2'-azo-bisisobutyronitrile; tri-n-butyl-tin hydride in 1,4-dioxane
Heating;
参考文献
Johnson, Richard; Joshi, Bhalchandra V.; Neidle, Stephen; Reese, Colin B.; Snook, Chris F.
Tetrahedron Letters, 1992 , vol. 33, # 52 p. 8151 - 8154
反应条件
2,2'-azo-bisisobutyronitrile; tri-n-butyl-tin hydride in 1,4-dioxane
Heating;
参考文献
Johnson, Richard; Joshi, Bhalchandra V.; Neidle, Stephen; Reese, Colin B.; Snook, Chris F.
Tetrahedron Letters, 1992 , vol. 33, # 52 p. 8151 - 8154
反应条件
1: 42 percent / 3 h / 132 °C
2: 43 percent / 29percent NH4OH / methanol / 12 h / Ambient temperature
View Scheme
参考文献
Shiragami; Irie; Shirae; Yokozeki; Yasuda
Journal of Organic Chemistry, 1988 , vol. 53, # 21 p. 5170 - 5173
反应条件
Amberlyst A-26 resin (F(1-)-form) in tetrahydrofuran
36 h; Heating;
参考文献
Larsen; Kofoed; Pedersen
Synthesis, 1995 , # 9 p. 1121 - 1125
反应条件
1: pyridine / 20 °C
2: aq. NaOH / methanol / Heating
3: 43 percent / NaH / dimethylformamide / 100 °C
View Scheme
参考文献
Mehellou, Youcef; McGuigan, Christopher; Brancale, Andrea; Balzarini, Jan
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 13 p. 3666 - 3669
反应条件
toluene-4-sulfonic acid in methanol; chloroform
0.75 h; Ambient temperature;
参考文献
Mansuri; Starrett Jr.; Wos; Tortolani; Brodfuehrer; Howell; Martin
Journal of Organic Chemistry, 1989 , vol. 54, # 20 p. 4780 - 4785
反应条件
ammonium hydroxide in methanol
12 h; Ambient temperature;
参考文献
Shiragami; Irie; Shirae; Yokozeki; Yasuda
Journal of Organic Chemistry, 1988 , vol. 53, # 21 p. 5170 - 5173
反应条件
1: aq. NaOH / methanol / Heating
2: 43 percent / NaH / dimethylformamide / 100 °C
View Scheme
参考文献
Mehellou, Youcef; McGuigan, Christopher; Brancale, Andrea; Balzarini, Jan
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 13 p. 3666 - 3669
反应条件
methanol; Dowex 50W H(1+) form
0.166667 h;
参考文献
Sheng, Jia; Hassan, Abdalla E. A.; Huang, Zhen
Journal of Organic Chemistry, 2008 , vol. 73, # 10 p. 3725 - 3729
