2’,3’-二脱氢-2’,3’-二脱氧尿苷合成路线 （共 55 条）
反应条件
hydrogen; palladium on activated charcoal in methanol 1 h;
参考文献
Ajinomoto Co., Inc.
Patent: US4962193 A1, 1990 ;
反应条件
1.1: 96 percent / H2 / Pd/C / methanol / 3.5 h / 20 °C / 760 Torr 2.1: iodine monochloride / methanol / 2 h / 20 °C 2.2: 70 percent / aq. ammonia / methanol View Scheme
参考文献
McGuigan, Christopher; Pathirana, Ranjith N.; Snoeck, Robert; Andrei, Graciela; De Clercq, Erik; Balzarini, Jan
Journal of Medicinal Chemistry, 2004 , vol. 47, # 7 p. 1847 - 1851
反应条件
1: 85 percent / pyridine / 24 h / 0 °C 2: 75 percent / H2 / 10percent Pd/C / ethanol / 2 h / 1292.9 Torr 3: 75 percent / 2,4-bis(4-methoxyphenyl)-1,3-dithia-2,4-diphosphetane 2,4-disulfide / toluene / 12 h / 80 °C 4: 70 percent / 1 N aq. NaOH / 6 h / Ambient temperature View Scheme
参考文献
Palomino; Meltsner; Kessel; Horwitz
Journal of Medicinal Chemistry, 1990 , vol. 33, # 1 p. 258 - 263
反应条件
sodium hydride in N,N-dimethyl-formamide
T=100°C; 3 h;
参考文献
McGuigan, Christopher; Pathirana, Ranjith N.; Snoeck, Robert; Andrei, Graciela; De Clercq, Erik; Balzarini, Jan
Journal of Medicinal Chemistry, 2004 , vol. 47, # 7 p. 1847 - 1851
反应条件
acetic anhydride in water
参考文献
Ajinomoto Co., Inc.
Patent: US4962193 A1, 1990 ;
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran
T=20°C;
参考文献
Nguyen, Corinne; Kasinathan, Ganasan; Leal-Cortijo, Isabel; Musso-Buendia, Alexander; Kaiser, Marcel; Brun, Reto; Ruiz-Perez, Luis M.; Johansson, Nils G.; Gonzalez-Pacanowska, Dolores; Gilbert, Ian H.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 19 p. 5942 - 5954
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran
1 h;
参考文献
Niihata; Kuno; Ebata; Matsushita
Bulletin of the Chemical Society of Japan, 1995 , vol. 68, # 8 p. 2327 - 2329
反应条件
ammonia in methanol
Ambient temperature;
参考文献
Talekar; Coe; Walker
Synthesis, 1993 , # 3 p. 303 - 306
反应条件
1: 75 percent / imidazole / dimethylformamide / 1.5 h / cooling
2: 60 percent / CHCl3 / 20 °C
3: 84 percent / trimethyl phosphite / 5 h / 118 °C
4: 78 percent / TBAF / tetrahydrofuran / 20 °C
View Scheme
参考文献
Nguyen, Corinne; Kasinathan, Ganasan; Leal-Cortijo, Isabel; Musso-Buendia, Alexander; Kaiser, Marcel; Brun, Reto; Ruiz-Perez, Luis M.; Johansson, Nils G.; Gonzalez-Pacanowska, Dolores; Gilbert, Ian H.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 19 p. 5942 - 5954
反应条件
sodium methylate in methanol
Ambient temperature;
参考文献
David, Serge; Sennyey, Gerard de
Carbohydrate Research, 1980 , vol. 82, p. 45 - 50
