2-(4-氯-苯基)-丙烷-1-醇合成路线 （共 10 条）
反应条件
molecular sieve; pyridinium chlorochromate in dichloromethane T=20°C; 8 h;
参考文献
Fernandes, Rodney A.; Kumar, Pradeep
Tetrahedron Letters, 2003 , vol. 44, # 6 p. 1275 - 1278
反应条件
1: With sodium hydrogencarbonate; palladium diacetate in DMF (N,N-dimethyl-formamide)
T=50°C; 7 h;
2: With sodium tetrahydroborate in DMF (N,N-dimethyl-formamide)
T=5°C; 0.5 h;
参考文献
Nissan Chemical Industries, Ltd.
Patent: US6407298 B1, 2002 ;
Location in patent: Page column 5 ;
反应条件
1: With [RhCl(η2:η2-cycloocta-1,5-diene)]2; N,N,N',N'-tetramethyl-1,4-butanediamine in acetonitrile
P=10351 Torr; Autoclave;
2: With hydrogen in acetonitrile
T=60°C; P=10351 Torr; 21 h; Autoclave;
参考文献
Cheung, Lawrence L. W.; Vasapollo, Giuseppe; Alper, Howard
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 10 p. 2019 - 2022
反应条件
sodium hydroxide in tetrahydrofuran; water
参考文献
FMC Corporation
Patent: US5502054 A1, 1996 ;
反应条件
sodium tetrahydroborate; zwitterionic rhodium ν6-tetraphenylborate; isopropyl alcohol in dichloromethane
T=100°C; P=25857.4 Torr; 22 h; Yield given. Yields of byproduct given;
参考文献
Zhou, Jian-Qiang; Alper, Howard
Journal of the Chemical Society, Chemical Communications, 1991 , # 4 p. 233 - 234
反应条件
1.1: Mg / diethyl ether
1.2: KHSO4 / Heating
2.1: chiral borane (IPC)28H; H2O2; KOH / tetrahydrofuran; ethanol
View Scheme
参考文献
Garner, Charles M.; Chiang, Shirley; Nething, Matthew; Monestel, Robert
Tetrahedron Letters, 2002 , vol. 43, # 46 p. 8339 - 8342
反应条件
sodium hydroxide; borane-THF; dihydrogen peroxide
1.) THF, 24 h, r.t.; 2.) 30 min; 3.) 1 h;
参考文献
Cook, Michael J.; Khan, Tauqeer A.; Nasri, Khalida
Tetrahedron, 1986 , vol. 42, # 1 p. 249 - 258
反应条件
1: bis(cyclopentadienyl)dimethyltitanium / tetrahydrofuran / 36 h / Inert atmosphere; Reflux
2: water; potassium carbonate / tetrahydrofuran; acetone / 16 h / Inert atmosphere
View Scheme
参考文献
Gansaeuer, Andreas; Klatte, Max; Braendle, Gerhard M.; Friedrich, Joachim
Angewandte Chemie - International Edition, 2012 , vol. 51, # 35 p. 8891 - 8894
反应条件
1: KHSO4, benzene-1,2-diol, picric acid / 220 °C
2: (i) NaBH4, BF3-Et2O, (EtOCH2CH2)2O, (ii) aq. NaOH, aq. H2O2
View Scheme
参考文献
DePuy,C.H. et al.
Journal of Organic Chemistry, 1970 , vol. 35, p. 2746 - 2750
反应条件
(i) HCl, EtOH, (ii) NaBH4, LiI*2H2O, MeCN; Multistep reaction;
参考文献
Heeres; Backx; Van Cutsem
Journal of Medicinal Chemistry, 1976 , vol. 19, # 9 p. 1148 - 1155
