2-氧代戊烷-1,5-二甲酸二乙酯合成路线 （共 51 条）
反应条件
sodium tetrahydroborate
参考文献
Drioli, Sara; Nitti, Patrizia; Pitacco, Giuliana; Tossut, Laura; Valentin, Ennio
Tetrahedron Asymmetry, 1999 , vol. 10, # 14 p. 2713 - 2728
反应条件
1: 57 percent / POCl3, conc. H2SO4 / benzene / Heating
2: 1.) KI / 1.) ethanol, 2.) ethanol, RT, 2 h
3: 60 percent / LiAlH4 / tetrahydrofuran / -10 °C
4: N-bromosuccinimide (NBS) / CHCl3 / 0.17 h / Ambient temperature
5: H2, Et3N / 10percent Pd/C / methanol / 0.33 h / Ambient temperature
View Scheme
参考文献
Shin; Sato; Honda; Yoshimura
Bulletin of the Chemical Society of Japan, 1983 , vol. 56, # 9 p. 2652 - 2656
反应条件
ethanol; hydrazine hydrate
参考文献
Gault et al.
Bulletin de la Societe Chimique de France, 1954 , p. 916
反应条件
1.1: 86 percent / NaI; In / H2O; ethanol / 20 °C
2.1: NaIO4; RuCl3 / ethyl acetate; acetonitrile; H2O / 1 h / 20 °C
2.2: AcCl / 0 - 20 °C
2.3: 1.18 g / CF3CO2H / 24 h / Heating
View Scheme
参考文献
Chen, Hong-Bin; Chen, Ling-Yan; Huang, Pei-Qiang; Zhang, Hong-Kui; Zhou, Zhao-Hui; Tsai, Khi-Rui
Tetrahedron, 2007 , vol. 63, # 10 p. 2148 - 2152
反应条件
in dichloromethane; water
参考文献
The University of Chicago
Patent: US4324730 A1, 1982 ;
反应条件
1: 96 percent / NaH / tetrahydrofuran / 0.5 h
2: 65 percent / 2N aq. KOH / ethanol / 1 h / Heating; extraction at pH 2
View Scheme
参考文献
Wang, Wenjun; Li, Lei; Jin, Chen; Niu, Yujie; Li, Sen; Ma, Ji; Li, Linfeng; Liu, Yu; Cai, Li; Zhao, Wei; Wang, Peng George
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 17 p. 5041 - 5044
反应条件
1: With hydrogen; CN; 5percent Pt/Al2O3 in acetic acid
T=20°C; Catalytic hydrogenation; P=750.075 Torr;
2: With toluene-4-sulfonic acid in acetic acid
Cyclization; Further stages. Title compound not separated from byproducts.;
参考文献
Balazsik, Katalin; Szoeri, Kornel; Felfoeldi, Karoly; Toeroek, Bela; Bartok, Mihaly
Chemical Communications, 2000 , # 7 p. 555 - 556
反应条件
Mucor rouxii freeze-dried yeast-like cells in hexane; water
T=28°C; 24 h;
参考文献
Drioli, Sara; Nitti, Patrizia; Pitacco, Giuliana; Tossut, Laura; Valentin, Ennio
Tetrahedron Asymmetry, 1999 , vol. 10, # 14 p. 2713 - 2728
反应条件
hydrogen; CD; 5percent Pt/Al2O3 (E4759) in acetic acid
T=20°C; Catalytic hydrogenation; P=750.075 Torr; Product distribution; Further Variations:ReagentsSolventsCatalysts;
参考文献
Balazsik, Katalin; Szoeri, Kornel; Felfoeldi, Karoly; Toeroek, Bela; Bartok, Mihaly
Chemical Communications, 2000 , # 7 p. 555 - 556
反应条件
Mucor rouxii yeast-like cells in hexane; water
T=28°C; 24 h;
参考文献
Rustoy, Eduardo M.; Pereyra, Elba N.; Moreno, Silvia; Baldessari, Alicia
Tetrahedron Asymmetry, 2004 , vol. 15, # 23 p. 3763 - 3768
