N-甲基-4-氨基苯甲醚合成路线 （共 125 条）
反应条件
BrettPhos palladium(II) phenethylamine chloride; sodium t-butanolate in tetrahydrofuran; tert-butyl alcohol T=20°C; 2 h; Inert atmosphere;
参考文献
MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Patent: WO2009/76622 A2, 2009 ;
Location in patent: Page/Page column 128-129 ;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 2 h; Heating / reflux;
参考文献
Dupont Pharmaceuticals
Patent: US2006/25407 A1, 2006 ;
Location in patent: Page/Page column 46 ;
反应条件
copper in water T=100°C; Ullmann reaction; 12 h;
参考文献
Jiao, Jiao; Zhang, Xi-Ru; Chang, Ning-Hui; Wang, Jie; Wei, Jun-Fa; Shi, Xian-Ying; Chen, Zhan-Guo
Journal of Organic Chemistry, 2011 , vol. 76, # 4 p. 1180 - 1183
参考文献
Journal of Pharmacology and Experimental Therapeutics, , vol. 55, p. 152,153,156
反应条件
butyl triphenylphosphonium tetraborate T=20°C; 0.183333 h;
参考文献
Hajipour; Mohammadpoor-Baltork; Noroallhi
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2001 , vol. 40, # 2 p. 152 - 156
反应条件
sodium bis(2-methoxyethoxy)aluminium dihydride in toluene 0.166667 h;
参考文献
Stanetty, Peter; Kasemann, Olaf; Schmid, Martin
Journal of Chemical Research, Miniprint, 1995 , # 9 p. 2101 - 2110
反应条件
1-chloro-3-nitrobenzene in benzene 3 h; Irradiation; Yield given;
参考文献
Tetrahedron Letters, , vol. 23, # 15 p. 1553 - 1556
反应条件
CuCN in tetrahydrofuran T=-50 - 20°C; Arylation; 2 h;
参考文献
Bernardi, Paolo; Dembech, Pasquale; Fabbri, Gaia; Ricci, Alfredo; Seconi, Giancarlo
Journal of Organic Chemistry, 1999 , vol. 64, # 2 p. 641 - 643
反应条件
potassium carbonate in DMF (N,N-dimethyl-formamide) T=125°C; 5 h;
参考文献
US2004/127747 A1, ;
Page 5 ;
反应条件
hydrogen; palladium on activated charcoal in dichloromethane P=760 Torr; Ambient temperature;
参考文献
Montevecchi, P. Carlo; Spagnolo, Piero
Journal of Organic Chemistry, 1982 , vol. 47, p. 1996 - 2000
