3-(4-甲氧基苯基)吡啶合成路线 （共 64 条）
反应条件
hydrogenchloride; sodium nitrite
参考文献
Leclerc, Gerard; Marciniak, Gilbert; Decker, Nicole; Schwartz, Jean
Journal of Medicinal Chemistry, 1986 , vol. 29, # 12 p. 2427 - 2432
反应条件
tin(ll) chloride in 1,4-dioxane
24 h; Heating;
参考文献
Ho; Ho, Tse-Lok; Liao; Liao, Po-Yau
Tetrahedron Letters, 1994 , vol. 35, # 14 p. 2211 - 2212
反应条件
palladium diacetate in N,N-dimethyl-formamide
Heating;
参考文献
Somei, Masanori; Yamada, Fumio; Naka, Katsumi
Chemical and Pharmaceutical Bulletin, 1987 , vol. 35, # 3 p. 1322 - 1326
反应条件
1.1: 7.5 g / diethyl ether / 12 h / Heating
2.1: tetrabutylammonium fluoride trihydrate / tetrahydrofuran; H2O / 1 h / 20 °C
2.2: 92 percent / 2-dicyclohexylphosphino-2',4',6'-triisopropylbiphenyl / [(η3-C3H5)PdCl]2 / tetrahydrofuran; H2O / 6 h / 80 °C
View Scheme
参考文献
Sahoo, Akhila K.; Oda, Takuro; Nakao, Yoshiaki; Hiyama, Tamejiro
Advanced Synthesis and Catalysis, 2004 , vol. 346, # 13-15 p. 1715 - 1727
反应条件
1: 4-MeOC6H4MgX, X = halide With zinc(II) chloride in tetrahydrofuran
T=25°C; 0.25 h; Inert atmosphere;
2: 3-bromo-pyridine With [(C10H13-1,3-(CH2P(Cy)2)2)Pd(Cl)] in tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one
T=100°C; Negishi cross-coupling reaction; Inert atmosphereResealed tube;
参考文献
Gerber, Roman; Blacque, Olivier; Frech, Christian M.
Dalton Transactions, 2011 , vol. 40, # 35 p. 8996 - 9003
反应条件
1: 3-bromo-pyridine With lithium chloride; zinc in tetrahydrofuran
T=20°C; Inert atmosphereReflux;
2: para-iodoanisole With tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran
T=20°C; 1 h; Inert atmosphere;
参考文献
Kim, Seung-Hoi; Slocum, Tim B.; Rieke, Reuben D.
Synthesis, 2009 , # 22 art. no. M02609SS, p. 3823 - 3827
反应条件
1.1: potassium phosphate; CuSO4‵5H2O; 1,10-phenanthroline / toluene / 48 h / Inert atmosphere; Reflux
2.1: N,N,N',N,-tetramethylethylenediamine; sec.-butyllithium / tetrahydrofuran; cyclohexane / 1 h / -78 °C / Inert atmosphere
2.2: -78 - 20 °C / Inert atmosphere
View Scheme
参考文献
Gati, Wafa; Rammah, Mohamed M.; Rammah, Mohamed B.; Couty, Francois; Evano, Gwilherm
Journal of the American Chemical Society, 2012 , vol. 134, # 22 p. 9078 - 9081
反应条件
1: 2,6-dimethylpyridine / chloroform / 0 - 20 °C
2: potassium phosphate; bis(1,5-cyclooctadiene)nickel (0); tri-cyclo-hexyl-phosphine / tetrahydrofuran / 12 h / 25 °C / Inert atmosphere
View Scheme
参考文献
Leowanawat, Pawaret; Zhang, Na; Resmerita, Ana-Maria; Rosen, Brad M.; Percec, Virgil
Journal of Organic Chemistry, 2011 , vol. 76, # 24 p. 9946 - 9955
反应条件
2,2'-azo-bisisobutyronitrile; tris-(trimethylsilyl)silane; acetic acid
T=80°C; 32 h;
参考文献
Nunez, Araceli; Sanchez, Aranzazu; Burgos, Carolina; Alvarez-Builla, Julio
Tetrahedron, 2004 , vol. 60, # 29 p. 6217 - 6224
反应条件
1,10-phenanthroline; palladium diacetate; caesium carbonate
T=140°C; 48 h; Sealed tube;
参考文献
Ye, Mengchun; Gao, Guo-Lin; Edmunds, Andrew J. F.; Worthington; Morris, James A.; Yu, Jin-Quan
Journal of the American Chemical Society, 2011 , vol. 133, # 47 p. 19090 - 19093
