3-(4-甲氧基苯基)吡啶合成路线 （共 64 条）
反应条件
sodium hydroxide; tetrabutylammomium bromide; 4,4'-dichlorobenzophenone oxime-derived palladacycle
T=120°C; Hiyama coupling; P=7500.6 Torr; 0.166667 h; microwave irradiation;
参考文献
Alacid, Emilio; Najera, Carmen
Advanced Synthesis and Catalysis, 2006 , vol. 348, # 7-8 p. 945 - 952
反应条件
1,3-bis-(diphenylphosphino)propane; potassium carbonate; nickel dichloride in 1,4-dioxane
T=100°C; Suzuki-Miyaura coupling; Inert atmosphere;
参考文献
Zhao, Yu-Long; Li, You; Li, Yu; Gao, Lian-Xun; Han, Fu-She
Chemistry - A European Journal, 2010 , vol. 16, # 17 p. 4991 - 4994
反应条件
anhydrous dipotassium phosphate; [1,3-bis(diphenylphosphino) propane] dichloronickel(II) in 1,4-dioxane
T=100 - 110°C; Suzuki-Miyaura coupling reaction; Inert atmosphere;
参考文献
Gao, Han; Li, You; Zhou, Yi-Guo; Han, Fu-She; Lin, Ying-Jie
Advanced Synthesis and Catalysis, 2011 , vol. 353, # 2-3 p. 309 - 314
反应条件
palladium diacetate; tris-(o-tolyl)phosphine in toluene
T=20°C; 5 h; Inert atmosphere;
参考文献
Chen, Xu; Zhou, Lingmin; Li, Yimei; Xie, Tao; Zhou, Shuangliu
Journal of Organic Chemistry, 2014 , vol. 79, # 1 p. 230 - 239
反应条件
potassium carbonate in ethanol; water
T=90°C; Suzuki Coupling; 0.25 h; Microwave irradiation;
参考文献
Bratt, Emma; Verho, Oscar; Johansson, Magnus J; Baeckvall, Jan-Erling
Journal of Organic Chemistry, 2014 , vol. 79, # 9 p. 3946 - 3954
反应条件
1: 3-hydroxy-pyridine With potassium phosphate; triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate in 1,4-dioxane
T=100°C; 3 h; Inert atmosphere;
2: (4-methoxyphenyl)-boronic acid With [1,3-bis(diphenylphosphino) propane] dichloronickel(II) in 1,4-dioxane
T=100 - 110°C; Suzuki-Miyaura coupling; Inert atmosphere;
参考文献
Chen, Guo-Jun; Huang, Jie; Gao, Lian-Xun; Han, Fu-She
Chemistry - A European Journal, 2011 , vol. 17, # 14 p. 4038 - 4042
反应条件
1: 1-methoxy-4-chlorobenzene With tetrahydroxydiboron; ethanol; XPhos-Pd-G2; potassium acetate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl
T=80°C; Miyaura Borylation Reaction; 2 h; Inert atmosphere;
2: 3-chloro-pyridine With potassium carbonate in water
T=80°C; Suzuki Coupling; 15 h; Inert atmosphere;
参考文献
Molander, Gary A.; Trice, Sarah L. J.; Kennedy, Steven M.
Journal of Organic Chemistry, 2012 , vol. 77, # 19 p. 8678 - 8688
反应条件
1: 1-methoxy-4-chlorobenzene With tetrahydroxydiboron; ethanol; XPhos-Pd-G2; potassium acetate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl
T=80°C; Miyaura Borylation Reaction; 2 h; Inert atmosphere;
2: 3-bromo-pyridine With potassium carbonate in water
T=80°C; Suzuki Coupling; 15 h; Inert atmosphere;
参考文献
Molander, Gary A.; Trice, Sarah L. J.; Kennedy, Steven M.
Journal of Organic Chemistry, 2012 , vol. 77, # 19 p. 8678 - 8688
反应条件
potassium phosphate; Ni(PCy3)2Cl2; PCy3∙HBF4 in o-xylene
T=150°C; Suzuki-Miyaura cross-coupling; 5 - 20 h; Inert atmosphere;
参考文献
Quasdorf, Kyle W.; Antoft-Finch, Aurora; Liu, Peng; Silberstein, Amanda L.; Komaromi, Anna; Blackburn, Tom; Ramgren, Stephen D.; Houk; Snieckus, Victor; Garg, Neil K.
Journal of the American Chemical Society, 2011 , vol. 133, # 16 p. 6352 - 6363
反应条件
palladium diacetate; potassium carbonate in dimethyl sulfoxide
T=60°C; Suzuki Coupling; Inert atmosphere;
参考文献
Liu, Jin-Biao; Yan, Hui; Chen, Hui-Xuan; Luo, Yu; Weng, Jiang; Lu, Gui
Chemical Communications, 2013 , vol. 49, # 46 p. 5268 - 5270
