3-(4-甲氧基苯基)吡啶合成路线 （共 64 条）
反应条件
caesium carbonate; cyclopallated ferrocenylimine c in water; N,N-dimethyl-formamide
T=110°C; Suzuki cross-coupling reaction; 24 h;
参考文献
Zhang, Jinli; Zhao, Liang; Song, Maoping; Mak, Thomas C.W.; Wu, Yangjie
Journal of Organometallic Chemistry, 2006 , vol. 691, # 6 p. 1301 - 1306
反应条件
potassium phosphate; [1,3-bis(diphenylphosphino) propane] dichloronickel(II) in 1,4-dioxane
T=100 - 110°C; Suzuki coupling; Inert atmosphere;
参考文献
Chen, Guo-Jun; Han, Fu-She
European Journal of Organic Chemistry, 2012 , # 19 p. 3575 - 3579
反应条件
1: 1-chloro-1-(4'-methoxyphenyl)silacyclobutane With tetrabutyl ammonium fluoride in tetrahydrofuran
2: 3-iodo-pyridine With tri-tert-butyl phosphine; tetrabutyl ammonium fluoride; bis(η3-allyl-μ-chloropalladium(II)) in tetrahydrofuran
5 h; Heating; Further stages.;
参考文献
Denmark, Scott E.; Wu, Zhicai
Organic Letters, 1999 , vol. 1, # 9 p. 1495 - 1498
反应条件
[(P{(NC5H10)(C6H11)2})2Pd(Cl)2] in tetrahydrofuran; 1-methyl-pyrrolidin-2-one
T=100°C; Negishi cross-coupling reaction; 0.166667 h; In air;
参考文献
Bolliger, Jeanne L.; Frech, Christian M.
Chemistry - A European Journal, 2010 , vol. 16, # 36 p. 11072 - 11081
反应条件
1: With N,N,N',N,-tetramethylethylenediamine; sec.-butyllithium in tetrahydrofuran; cyclohexane
T=-78°C; 1 h; Inert atmosphere;
2: With 3,4,5,6-tetrachloro-1,2-benzoquinone; acetic acid in tetrahydrofuran; cyclohexane
T=-78 - 20°C; Inert atmosphere; chemoselective reaction;
参考文献
Gati, Wafa; Rammah, Mohamed M.; Rammah, Mohamed B.; Evano, Gwilherm
Beilstein Journal of Organic Chemistry, 2012 , vol. 8, p. 2214 - 2222
反应条件
1: 1-bromo-4-methoxy-benzene With magnesium in tetrahydrofuran
2: With zinc dibromide in tetrahydrofuran
3: 3-bromo-pyridine With 4-(N,N-dimethlyamino)pyridine; phosphonic acid diethyl ester; nickel dichloride in tetrahydrofuran
T=25°C; Negishi cross-coupling; 2 h;
参考文献
Gavryushin, Andrei; Kofink, Christiane; Manolikakes, Georg; Knochel, Paul
Tetrahedron, 2006 , vol. 62, # 32 p. 7521 - 7533
反应条件
1: 1-bromo-4-methoxy-benzene With tetrahydroxydiboron; ethanol; XPhos-Pd-G2; potassium acetate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl
T=80°C; Miyaura Borylation Reaction; 2.5 h; Inert atmosphere;
2: 3-chloro-pyridine With potassium carbonate in water
T=80°C; Suzuki Coupling; 15 h; Inert atmosphere;
参考文献
Molander, Gary A.; Trice, Sarah L. J.; Kennedy, Steven M.
Journal of Organic Chemistry, 2012 , vol. 77, # 19 p. 8678 - 8688
反应条件
bis(1,5-cyclooctadiene)nickel (0); potassium phosphate; tri-cyclo-hexyl-phosphine in tetrahydrofuran
T=25°C; 12 h; Inert atmosphere;
参考文献
Leowanawat, Pawaret; Zhang, Na; Resmerita, Ana-Maria; Rosen, Brad M.; Percec, Virgil
Journal of Organic Chemistry, 2011 , vol. 76, # 24 p. 9946 - 9955
反应条件
bis(1,5-cyclooctadiene)nickel (0); potassium phosphate; tri-cyclo-hexyl-phosphine in tetrahydrofuran
T=25°C; 12 h; Inert atmosphere;
参考文献
Leowanawat, Pawaret; Zhang, Na; Safi, Mehtap; Hoffman, David J.; Fryberger, Miriam C.; George, Aiswaria; Percec, Virgil
Journal of Organic Chemistry, 2012 , vol. 77, # 6 p. 2885 - 2892
反应条件
tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran
T=20°C; 1 h; Inert atmosphere;
参考文献
Kim, Seung-Hoi; Rieke, Reuben D.
Tetrahedron, 2010 , vol. 66, # 17 p. 3135 - 3146
