3-(4-甲氧基苯基)吡啶合成路线 （共 64 条）
反应条件
PinP(O)H; [Pd(dibenzylideneacetone)2] in tetrahydrofuran; 1,4-dioxane
T=80°C; Kumada cross-coupling reaction; 22 h;
参考文献
Ackermann, Lutz; Althammer, Andreas
Organic Letters, 2006 , vol. 8, # 16 p. 3457 - 3460
反应条件
bis-triphenylphosphine-palladium(II) chloride; sodium lauryl sulfate; potassium carbonate; p-toluenesulfonyl chloride in water
T=60°C; Suzuki Coupling;
参考文献
Liu, Jin-Biao; Zhou, He-Ping; Peng, Yi-Yuan
Tetrahedron Letters, 2014 , vol. 55, # 17 p. 2872 - 2875
反应条件
1: triallyl(4-methoxyphenyl)silane With tetrabutyl ammonium fluoride in tetrahydrofuran; water
T=20°C; 1 h;
2: 3-chloro-pyridine With 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl; bis(η3-allyl-μ-chloropalladium(II)) in tetrahydrofuran; water
T=80°C; 6 h;
参考文献
Sahoo, Akhila K.; Nakao, Yoshiaki; Hiyama, Tamejiro
Chemistry Letters, 2004 , vol. 33, # 5 p. 632 - 633
反应条件
1: p-MeOC6H4MnCl With IPr*hydrochloride; bis(acetylacetonate)nickel(II) in tetrahydrofuran
T=0°C; 0.5 h;
2: 3-bromo-pyridine in tetrahydrofuran
T=0 - 25°C; 1 h;
参考文献
Leleu, Anne; Fort, Yves; Schneider, Raphael
Advanced Synthesis and Catalysis, 2006 , vol. 348, # 9 p. 1086 - 1092
反应条件
1: (4-methoxyphenyl)-boronic acid T=75°C; 4 h; dehydrationvacuum;
2: 3-(N,N-diethylcarbamoyloxy)-pyridine With potassium phosphate; NiCl2(PCy3)2; PCy3∙HBF4 in o-xylene
T=150°C; Suzuki-Miyaura coupling; 5 h; Inert atmosphere;
参考文献
Antoft-Finch, Aurora; Blackburn, Tom; Snieckus, Victor
Journal of the American Chemical Society, 2009 , vol. 131, # 49 p. 17750 - 17752
反应条件
sodium hydroxide; [PdCl2(P(3,4-(18-crown-6)-phenyl)2(C6H5))2]
T=140°C; 1.5 h;
参考文献
Gordillo, Alvaro; De Jesus, Ernesto; Lopez-Mardomingo, Carmen
Organic Letters, 2006 , vol. 8, # 16 p. 3517 - 3520
反应条件
anhydrous dipotassium phosphate; [1,3-bis(diphenylphosphino) propane] dichloronickel(II) in 1,4-dioxane
T=100 - 110°C; Suzuki-Miyaura coupling reaction; Inert atmosphere;
参考文献
Gao, Han; Li, You; Zhou, Yi-Guo; Han, Fu-She; Lin, Ying-Jie
Advanced Synthesis and Catalysis, 2011 , vol. 353, # 2-3 p. 309 - 314
反应条件
sodium hydroxide; palladium diacetate
T=60°C; Hiyama reaction; 6 h;
参考文献
Shi, Shengyin; Zhang, Yuhong
Journal of Organic Chemistry, 2007 , vol. 72, # 15 p. 5927 - 5930
反应条件
potassium fluoride; palladium diacetate; tris-(o-tolyl)phosphine in N,N-dimethyl-formamide
T=120°C;
参考文献
Hatanaka, Yasuo; Goda, Ken-ichi; Okahara, Yoshinori; Hiyama, Tamejiro
Tetrahedron, 1994 , vol. 50, # 28 p. 8301 - 8316
反应条件
potassium phosphate; tetrakis(triphenylphosphine) palladium(0) in 1,4-dioxane
T=85°C; 5 h;
参考文献
Oh-e, Takayuki; Miyaura, Norio; Suzuki, Akira
Journal of Organic Chemistry, 1993 , vol. 58, # 8 p. 2201 - 2208
