3-(4-甲氧基苯基)吡啶合成路线 （共 64 条）
反应条件
hydrogenchloride; hydrogen; platinum(IV) oxide in methanol P=2585.7 Torr;
参考文献
Hacksell, Uli; Arvidsson, Lars-Erik; Svensson, Uno; Nilsson, J. Lars G.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 12 p. 1475 - 1482
反应条件
potassium carbonate in isopropyl alcohol
T=85 - 90°C; Suzuki-Miyaura Coupling; 24 h;
参考文献
Santra, Subhankar; Hota, Pradip Kumar; Bhattacharyya, Rangeet; Bera, Parthasarathi; Ghosh, Prasenjit; Mandal, Swadhin K.
ACS Catalysis, 2013 , vol. 3, # 12 p. 2776 - 2789
反应条件
potassium phosphate; palladium dichloride; S-2,2',6,6'-tetramethoxy-4,4'-bis(diphenylphosphino)-3,3'-bipyridine in butan-1-ol
T=100°C; Suzuki coupling; 20 h; Inert atmosphere;
参考文献
Fu, Xing-Li; Wu, Lei-Lei; Fu, Hai-Yan; Chen, Hua; Li, Rui-Xiang
European Journal of Organic Chemistry, 2009 , # 13 p. 2051 - 2054
反应条件
1-ethyl-2-pyrrolidinone; 4-(N,N-dimethlyamino)pyridine; phosphonic acid diethyl ester; nickel dichloride; zinc dibromide in tetrahydrofuran
T=20°C; 2 h;
参考文献
knochel, Paul; Gavriushin, Andrei; Kofink, Christiane Charlotte; Manolikakes, Georg
Patent: US2010/184977 A1, 2010 ;
Location in patent: Page/Page column 5 ;
反应条件
copper(l) iodide; C37H51ClFeNPPd; cesium fluoride in N,N-dimethyl-formamide
T=80°C; Stille Cross Coupling; 12 h; Inert atmosphere;
参考文献
Ma, Gaizhi; Leng, Yuting; Wu, Yusheng; Wu, Yangjie
Tetrahedron, 2013 , vol. 69, # 2 p. 902 - 909
反应条件
copper(l) iodide; C37H51ClFeNPPd; cesium fluoride in N,N-dimethyl-formamide
T=20°C; Stille Cross Coupling; 12 h; Inert atmosphere;
参考文献
Ma, Gaizhi; Leng, Yuting; Wu, Yusheng; Wu, Yangjie
Tetrahedron, 2013 , vol. 69, # 2 p. 902 - 909
反应条件
copper(l) iodide; C52H67ClFeNPPd; cesium fluoride in N,N-dimethyl-formamide
T=110°C; Stille Cross Coupling; 12 h; Inert atmosphere;
参考文献
Ma, Gaizhi; Leng, Yuting; Wu, Yusheng; Wu, Yangjie
Tetrahedron, 2013 , vol. 69, # 2 p. 902 - 909
反应条件
1: 3-fluoropyridine With HASPO; Ni(acac)2 in tetrahydrofuran
T=20°C; 0.0833333 h;
2: 4-methoxyphenyl magnesium bromide in tetrahydrofuran
T=20°C; Kumada cross-coupling; 24 h;
参考文献
Ackermann, Lutz; Born, Robert; Spatz, Julia H.; Meyer, Daniel
Angewandte Chemie - International Edition, 2005 , vol. 44, # 44 p. 7216 - 7219
反应条件
1: 3-chloro-pyridine With HASPO; Ni(acac)2 in tetrahydrofuran
T=20°C; 0.0833333 h;
2: 4-methoxyphenyl magnesium bromide in tetrahydrofuran
T=20°C; Kumada cross-coupling; 4 h;
参考文献
Ackermann, Lutz; Born, Robert; Spatz, Julia H.; Meyer, Daniel
Angewandte Chemie - International Edition, 2005 , vol. 44, # 44 p. 7216 - 7219
反应条件
NHC-Pd(II)-Im; potassium tert-butylate in water
T=80°C; Suzuki-Miyaura coupling; 12 h;
参考文献
Zhou, Xia-Xia; Shao, Li-Xiong
Synthesis, 2011 , # 19 art. no. H53711SS, p. 3138 - 3142
