4-(四氢吡喃-2-基氧基)-1-丁烯合成路线 （共 10 条）
反应条件
1.) hydroboration, 2.) modified Moffatt oxidation Yield given;
参考文献
Castelhano, Arlindo L.; Krantz, Allen
Journal of the American Chemical Society, 1987 , vol. 109, # 11 p. 3491 - 3493
反应条件
1: 2-(but-3-en-1-yloxy)tetrahydro-2H-pyran; tribromo methane With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide 2: methyl iodide With n-butyllithium Further stages;
参考文献
Ohmura, Toshimichi; Taniguchi, Hiroki; Suginome, Michinori
Organic Letters, 2009 , vol. 11, # 13 p. 2880 - 2883
反应条件
toluene-4-sulfonic acid in diethyl ether
5 h; Ambient temperature;
参考文献
Li, Ding; Zhou, Hui-Qiang; Dakoji, Srikanth; Shin, Injae; Oh, Eugene; Liu, Hung-Wen
Journal of the American Chemical Society, 1998 , vol. 120, # 9 p. 2008 - 2017
反应条件
n-butyllithium; lithium iodide in tetrahydrofuran; hexane
from 0 degC to room temp.;
参考文献
Alcaraz; Harnett; Mioskowski; Martel; Le Gall; Shin, Dong-Soo; Falck
Tetrahedron Letters, 1994 , vol. 35, # 30 p. 5453 - 5456
反应条件
nickel(0){1,2-bis(diphenylphosphino)ethane} in diethyl ether
1.) 0 deg C; 2.) rt, 24 h; Yield given. Yields of byproduct given;
参考文献
Menicagli, R.; Malanga, C.; Finato, B.; Lardicci, L.
Tetrahedron Letters, 1988 , vol. 29, # 27 p. 3373 - 3374
反应条件
Yield given. Multistep reaction;
参考文献
Swanson, Douglas R.; Nguyen, Thinh; Noda, Yumiki; Negishi, Ei-ichi
Journal of Organic Chemistry, 1991 , vol. 56, # 7 p. 2590 - 2591
反应条件
nickel(0){1,2-bis(diphenylphosphino)ethane} in diethyl ether
1.) 0 deg C; 2.) rt, 22 h; Yield given. Yields of byproduct given;
参考文献
Menicagli, R.; Malanga, C.; Finato, B.; Lardicci, L.
Tetrahedron Letters, 1988 , vol. 29, # 27 p. 3373 - 3374
反应条件
1: 1.) hydroboration, 2.) modified Moffatt oxidation
2: 1.5M n-BuLi
View Scheme
参考文献
Castelhano, Arlindo L.; Krantz, Allen
Journal of the American Chemical Society, 1987 , vol. 109, # 11 p. 3491 - 3493
反应条件
3-chloro-benzenecarboperoxoic acid in dichloromethane
T=0°C; 24 h;
参考文献
Research Triangle Institute
Patent: US2007/27182 A1, 2007 ;
Location in patent: Page/Page column 12 ;
US 20070027182 A1
反应条件
1: With ozone in dichloromethane
T=-78°C;
2: With triphenylphosphine in dichloromethane
T=-78 - 20°C; 18 h;
参考文献
Parsons, Scott R.; Hooper, Joel F.; Willis, Michael C.
Organic Letters, 2011 , vol. 13, # 5 p. 998 - 1000
