(1,1-二氧代四氢-2H-噻喃-4-基)氨基甲酸叔丁酯合成路线 (共 5 条)
反应条件
hydrogenchloride in ethyl acetate T=15 - 30°C; 19 h;
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP2261213 A1, 2010 ;
Location in patent: Page/Page column 53 ;
EP 2261213 A1
反应条件
trifluoroacetic acid in dichloromethane T=20°C; 0.5 h;
参考文献
GLAXOSMITHKLINE LLC; QIN, Donghui; CHRISTENSEN, Sieg; WU, Chengde; ZHANG, Zhiliu; YU, Haiyu; YUAN, Jiangxing
Patent: WO2013/149362 A1, 2013 ;
Location in patent: Page/Page column 60-61 ;
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / |Reflux
2: triethylamine / dichloromethane / 2 h
3: 3-chloro-benzenecarboperoxoic acid; triethylamine / dichloromethane
View Scheme
参考文献
GLAXOSMITHKLINE LLC; QIN, Donghui; CHRISTENSEN, Sieg; WU, Chengde; ZHANG, Zhiliu; YU, Haiyu; YUAN, Jiangxing
Patent: WO2013/149362 A1, 2013 ;
反应条件
1: triethylamine / dichloromethane / 2 h
2: 3-chloro-benzenecarboperoxoic acid; triethylamine / dichloromethane
View Scheme
参考文献
GLAXOSMITHKLINE LLC; QIN, Donghui; CHRISTENSEN, Sieg; WU, Chengde; ZHANG, Zhiliu; YU, Haiyu; YUAN, Jiangxing
Patent: WO2013/149362 A1, 2013 ;
反应条件
1: sodium acetate; hydroxylamine hydrochloride / ethanol
2: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / |Reflux
3: triethylamine / dichloromethane / 2 h
4: 3-chloro-benzenecarboperoxoic acid; triethylamine / dichloromethane
View Scheme
参考文献
GLAXOSMITHKLINE LLC; QIN, Donghui; CHRISTENSEN, Sieg; WU, Chengde; ZHANG, Zhiliu; YU, Haiyu; YUAN, Jiangxing
Patent: WO2013/149362 A1, 2013 ;