1,8-二叠氮基-3,5-二氧杂辛烷合成路线 （共 12 条）
反应条件
1: 82 percent / lithium aluminum hydride / tetrahydrofuran / 10 h / Heating 2: 60 percent / toluene / 1.)0 deg C, 7 h 2.)overnight 3: 85 percent / lithium aluminum hydride / tetrahydrofuran / 8 h / Heating View Scheme
参考文献
Gansow, Otto A.; Kausar, A. Rashid; Triplett, Kelly B.
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 297 - 302
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 10 h; Heating;
参考文献
Journal of Heterocyclic Chemistry, , vol. 18, p. 297 - 302
反应条件
Pt on charcoal in tetrahydrofuran
反应条件
1: 82 percent / lithium aluminum hydride / tetrahydrofuran / 10 h / Heating 2: 60 percent / toluene / 1.)0 deg C, 7 h 2.)overnight View Scheme
参考文献
Gansow, Otto A.; Kausar, A. Rashid; Triplett, Kelly B.
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 297 - 302
反应条件
1.1: hydrogenchloride; triphenylphosphine / water; toluene / 16 h / 0 - 20 °C 2.1: triethylamine / dichloromethane / 0.83 h 3.1: triphenylphosphine / tetrahydrofuran / 5 h 3.2: 2 h View Scheme
参考文献
ChemBioChem, , vol. 11, # 12 p. 1769 - 1781
反应条件
hydrogenchloride; triphenylphosphine in tetrahydrofuran; diethyl ether T=20°C; 12 h;
参考文献
Klein, Emmanuel; DeBonis, Salvatore; Thiede, Bernd; Skoufias, Dimitrios A.; Kozielski, Frank; Lebeau, Luc
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 19 p. 6474 - 6488
反应条件
sodium azide in N,N-dimethyl-formamide
参考文献
Gavrilyuk, Julia I.; Wuellner, Ulrich; Barbas III, Carlos F.
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 5 p. 1421 - 1424
反应条件
sodium azide; sodium iodide in acetonitrile
48 h; Heating;
参考文献
Klein, Emmanuel; DeBonis, Salvatore; Thiede, Bernd; Skoufias, Dimitrios A.; Kozielski, Frank; Lebeau, Luc
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 19 p. 6474 - 6488
反应条件
sodium azide in N,N-dimethyl-formamide
T=70°C; 12 h;
参考文献
Xiao, Junpeng; Tolbert, Thomas J.
Organic Letters, 2009 , vol. 11, # 18 p. 4144 - 4147
反应条件
sodium azide in N,N-dimethyl-formamide
T=60°C; 6 h;
参考文献
Li, Yi; Dong, Jianming; Xun, Zhiqing; Zeng, Yi; Yu, Tianjun; Han, Yongbin; Chen, Jinping; Li, Ying-Ying; Yang, Guoqiang
Chemistry - A European Journal, 2013 , vol. 19, # 24 p. 7931 - 7936
