(2S,3R)-3-氨基-2-羟基-4-苯丁酸合成路线 （共 35 条）
反应条件
Na-naphthalide in ethylene glycol dimethyl ether T=-78°C; 0.5 h;
参考文献
Jefford, Charles W.; McNulty, James; Lu, Zhi-Hui; Wang, Jian Bo
Helvetica Chimica Acta, 1996 , vol. 79, # 4 p. 1203 - 1216
反应条件
sodium tetrahydroborate; copper(II) nitrate in water T=0°C; 0.5 h;
参考文献
Journal of Organic Chemistry, , vol. 68, # 18 p. 7041 - 7045
反应条件
hydrogen; palladium on activated charcoal in methanol T=70°C; 12 h;
参考文献
Synthesis, , # 6 p. 829 - 836
反应条件
1: periodic acid; RuCl3 2: NaN3 / Cu(NO3)2 / H2O / 1.5 h / 65 °C 3: NaBH4 / Cu(NO3)2 / H2O / 0.5 h / 0 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 68, # 18 p. 7041 - 7045
反应条件
1: periodic acid; RuCl3 2: NaN3 / Cu(NO3)2 / H2O / 1.5 h / 65 °C 3: NaBH4 / Cu(NO3)2 / H2O / 0.5 h / 0 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 68, # 18 p. 7041 - 7045
反应条件
1: NaN3 / Cu(NO3)2 / H2O / 1.5 h / 65 °C 2: NaBH4 / Cu(NO3)2 / H2O / 0.5 h / 0 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 68, # 18 p. 7041 - 7045
反应条件
hydrogenchloride; ion exchange resin (H+) 1.) 4 h, 100 deg C;
参考文献
Kobayashi; Takemoto; Ito; Terashima
Tetrahedron Letters, 1990 , vol. 31, # 21 p. 3031 - 3034
反应条件
1: 81 percent / BBr3 / CH2Cl2 / 2 h / -78 °C 2: 79 percent / H2 / Pd/C / methanol / 15 h / Ambient temperature 3: 2 N aq. HCl View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 10, # 12 p. 2327 - 2336
反应条件
1: 79 percent / H2 / Pd/C / methanol / 15 h / Ambient temperature 2: 2 N aq. HCl View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 10, # 12 p. 2327 - 2336
反应条件
1: 93 percent / ImH / dimethylformamide / Ambient temperature 2: 80 percent / DIBAL / diethyl ether; hexane / 0.33 h / -78 °C 3: 100 percent / anhyd. MgSO4 / toluene / 0.83 h / 0 °C 4: NEt3 / CH2Cl2 / Ambient temperature 5: 70 percent / HCl 6: 93 percent / pyridine / CH2Cl2 / 0.17 h / 0 °C 7: 92 percent / H2 / 10percent Pd/C / ethyl acetate / Ambient temperature 8: 85 percent / 1.) 6 M HCl, 2.) ion exchange resin (H+) / 1.) 4 h, 100 deg C View Scheme
参考文献
Tetrahedron Letters, , vol. 31, # 21 p. 3031 - 3034
