3,4-二氨基苯甲醚盐酸盐合成路线

参考文献

Harper, Steven; McCauley, John A.; Rudd, Michael T.; Ferrara, Marco; DiFilippo, Marcello; Crescenzi, Benedetta; Koch, Uwe; Petrocchi, Alessia; Holloway, M. Katharine; Butcher, John W.; Romano, Joseph J.; Bush, Kimberly J.; Gilbert, Kevin F.; McIntyre, Charles J.; Nguyen, Kevin T.; Nizi, Emanuela; Carroll, Steven S.; Ludmerer, Steven W.; Burlein, Christine; Dimuzio, Jillian M.; Graham, Donald J.; McHale, Carolyn M.; Stahlhut, Mark W.; Olsen, David B.; Monteagudo, Edith; Cianetti, Simona; Giuliano, Claudio; Pucci, Vincenzo; Trainor, Nicole; Fandozzi, Christine M.; Rowley, Michael; Coleman, Paul J.; Vacca, Joseph P.; Summa, Vincenzo; Liverton, Nigel J.
ACS Medicinal Chemistry Letters, 2012 , vol. 3, # 4 p. 332 - 336

59548-39-93,4-二氨基苯甲醚盐酸盐+

144-62-7草酸

31910-18-62,3-二羟基-6-甲氧基喹噁啉

参考文献

MERCK SHARP and DOHME CORP.; MERCK SHARP and DOHME LIMITED; BEUTNER, Gregory, L.; WENSLOW, Robert, M., Jr.; CHOI, Eric, J.; SHULTZ, Clinton Scott; SCOTT, Jeremy; ARREDONDO, Juan, D.; ARTINO, Laura
Patent: WO2013/28465 A1, 2013 ;
Location in patent: Page/Page column 21 ;

59548-39-93,4-二氨基苯甲醚盐酸盐

31910-18-62,3-二羟基-6-甲氧基喹噁啉

参考文献

MERCK SHARP and DOHME CORP; Liverton, Nigel J.; McCauley, John A.; Rudd, Michael T.
Patent: US2012/121624 A1, 2012 ;
Location in patent: Page/Page column ;

924-44-7乙醛酸乙酯+

59548-39-93,4-二氨基苯甲醚盐酸盐

55686-93-62-氯-7-甲氧基喹噁啉+

55687-11-12-氯-6-甲氧基喹噁啉+

39267-04-42,3-二氯-6-甲氧基喹喔啉

参考文献

Shen, Hong C.; Szymonifka, Michael J.; Kharbanda, Divya; Deng, Qiaolin; Carballo-Jane, Ester; Wu, Kenneth K.; Wu, Tsuei-Ju; Cheng, Kang; Ren, Ning; Cai, Tian-Quan; Taggart, Andrew K.; Wang, Junying; Tong, Xinchun; Waters, M. Gerard; Hammond, Milton L.; Tata, James R.; Colletti, Steven L.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 24 p. 6723 - 6728

59548-39-93,4-二氨基苯甲醚盐酸盐

39267-04-42,3-二氯-6-甲氧基喹喔啉+

1206524-78-8+

1263814-66-9

参考文献

Harper, Steven; McCauley, John A.; Rudd, Michael T.; Ferrara, Marco; DiFilippo, Marcello; Crescenzi, Benedetta; Koch, Uwe; Petrocchi, Alessia; Holloway, M. Katharine; Butcher, John W.; Romano, Joseph J.; Bush, Kimberly J.; Gilbert, Kevin F.; McIntyre, Charles J.; Nguyen, Kevin T.; Nizi, Emanuela; Carroll, Steven S.; Ludmerer, Steven W.; Burlein, Christine; Dimuzio, Jillian M.; Graham, Donald J.; McHale, Carolyn M.; Stahlhut, Mark W.; Olsen, David B.; Monteagudo, Edith; Cianetti, Simona; Giuliano, Claudio; Pucci, Vincenzo; Trainor, Nicole; Fandozzi, Christine M.; Rowley, Michael; Coleman, Paul J.; Vacca, Joseph P.; Summa, Vincenzo; Liverton, Nigel J.
ACS Medicinal Chemistry Letters, 2012 , vol. 3, # 4 p. 332 - 336

59548-39-93,4-二氨基苯甲醚盐酸盐

39267-04-42,3-二氯-6-甲氧基喹喔啉

参考文献

MERCK SHARP and DOHME CORP.; MERCK SHARP and DOHME LIMITED; BEUTNER, Gregory, L.; WENSLOW, Robert, M., Jr.; CHOI, Eric, J.; SHULTZ, Clinton Scott; SCOTT, Jeremy; ARREDONDO, Juan, D.; ARTINO, Laura
Patent: WO2013/28465 A1, 2013 ;

59548-39-93,4-二氨基苯甲醚盐酸盐+

76-05-1三氟乙酸

887572-60-35-甲氧基苯并咪唑-2-甲酸

参考文献

Frohn, Mike; Xu, Han; Zou, Xiaoming; Chang, Catherine; McElvaine, Michele; Plant, Matthew H.; Wong, Min; Tagari, Philip; Hungate, Randall; Buerli, Roland W.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 23 p. 6633 - 6637

59548-39-93,4-二氨基苯甲醚盐酸盐

1206524-85-7MK-5172

参考文献

MERCK SHARP and DOHME CORP.; MERCK SHARP and DOHME LIMITED; BEUTNER, Gregory, L.; WENSLOW, Robert, M., Jr.; CHOI, Eric, J.; SHULTZ, Clinton Scott; SCOTT, Jeremy; ARREDONDO, Juan, D.; ARTINO, Laura
Patent: WO2013/28465 A1, 2013 ;

59548-39-93,4-二氨基苯甲醚盐酸盐

1350514-68-9Grazoprevir

参考文献

Harper, Steven; McCauley, John A.; Rudd, Michael T.; Ferrara, Marco; DiFilippo, Marcello; Crescenzi, Benedetta; Koch, Uwe; Petrocchi, Alessia; Holloway, M. Katharine; Butcher, John W.; Romano, Joseph J.; Bush, Kimberly J.; Gilbert, Kevin F.; McIntyre, Charles J.; Nguyen, Kevin T.; Nizi, Emanuela; Carroll, Steven S.; Ludmerer, Steven W.; Burlein, Christine; Dimuzio, Jillian M.; Graham, Donald J.; McHale, Carolyn M.; Stahlhut, Mark W.; Olsen, David B.; Monteagudo, Edith; Cianetti, Simona; Giuliano, Claudio; Pucci, Vincenzo; Trainor, Nicole; Fandozzi, Christine M.; Rowley, Michael; Coleman, Paul J.; Vacca, Joseph P.; Summa, Vincenzo; Liverton, Nigel J.
ACS Medicinal Chemistry Letters, 2012 , vol. 3, # 4 p. 332 - 336

924-44-7乙醛酸乙酯+

59548-39-93,4-二氨基苯甲醚盐酸盐

55686-93-62-氯-7-甲氧基喹噁啉+

55687-11-12-氯-6-甲氧基喹噁啉+

39267-04-42,3-二氯-6-甲氧基喹喔啉

参考文献

Shen, Hong C.; Szymonifka, Michael J.; Kharbanda, Divya; Deng, Qiaolin; Carballo-Jane, Ester; Wu, Kenneth K.; Wu, Tsuei-Ju; Cheng, Kang; Ren, Ning; Cai, Tian-Quan; Taggart, Andrew K.; Wang, Junying; Tong, Xinchun; Waters, M. Gerard; Hammond, Milton L.; Tata, James R.; Colletti, Steven L.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 24 p. 6723 - 6728