N-叔丁氧羰基-L-丝氨酸合成路线 （共 19 条）
反应条件
sodium hydrogencarbonate in 1,4-dioxane; water 2 h; Ambient temperature; Yield given;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 41, # 2 p. 252 - 261
反应条件
trifluoroacetic acid in dichloromethane T=20°C; 2 h;
参考文献
Cohen, Scott B.; Halcomb, Randall L.
Journal of the American Chemical Society, 2002 , vol. 124, # 11 p. 2534 - 2543
反应条件
1: pyridine / -5 °C 2: NaI / acetone / Ambient temperature 3: 1.) zinc dust, 2.) diethyl 4-phosphono(difluoromethyl)iodobenzene / 2.) (Ph3P)2PdCl2 / 1.) THF/N,N-dimethylacetamide, 65 deg C, 1 h, 2.) THF/N,N-dimethylacetamide, 65 deg C, 5 h View Scheme
参考文献
Smyth; Burke Jr.
Tetrahedron Letters, 1994 , vol. 35, # 4 p. 551 - 554
反应条件
1H-imidazole; iodine; triphenylphosphine in dichloromethane T=0°C; 2 h; Inert atmosphere;
参考文献
Koseki, Yohei; Yamada, Haruka; Usuki, Toyonobu
Tetrahedron Asymmetry, 2011 , vol. 22, # 5 p. 580 - 586
参考文献
NeoRx Corporation
Patent: US5112953 A1, 1992 ;
反应条件
1: With boron trifluoride diethyl etherate 2: With hydrogen; palladium on activated charcoal
参考文献
UNIVERSITY OF VIRGINIA PATENT FOUNDATION
Patent: WO2005/41899 A2, 2005 ;
Location in patent: Page/Page column 118 ;
WO 2005/041899 A2
反应条件
1: 84 percent / pyridine / 24 h / -10 °C
2: 80 percent / NaI / acetone / 24 h / Ambient temperature
3: 1) zinc-copper couple / 2) bis(tri-o-tolylphosphine)palladium trichloride / 1) DMA, benzene, sonication, 30 min, 2) DMA, benzene, 50 deg C, 1 h
View Scheme
参考文献
Jackson, Richard F. W.; Wishart, Neil; Wood, Anthony; James, Keith; Wythes, Martin J.
Journal of Organic Chemistry, 1992 , vol. 57, # 12 p. 3397 - 3404
参考文献
Walker, Michael A.; Kaplita, Khane Pham; Chen, Ti; King, H. Dalton
Synlett, 1997 , vol. 1997, # 2 p. 169 - 170
反应条件
methyl 4-hydroxy-benzoate; triphenylphosphine; diethylazodicarboxylate in benzene
15 h; Ambient temperature;
参考文献
Cherney, Robert J.; Wang, Li
Journal of Organic Chemistry, 1996 , vol. 61, # 7 p. 2544 - 2546
