BOC-MET-ENKEPHALIN合成路线 （共 19 条）
反应条件
hydrogenchloride; acetic acid 1 h;
参考文献
Masiukif.wicx, Elzbieta; Rzeszotarska, Barbara
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 11 p. 1672 - 1675
反应条件
propylamine
T=25°C; 0.0333333 h;
参考文献
Kemp, D. S.; Hanson, Gunnar
Journal of Organic Chemistry, 1981 , vol. 46, p. 4971 - 4975
反应条件
triethanolamine in diethyl ether; ethanol; water; acetonitrile
参考文献
Takeda Chemical Industries, Ltd.
Patent: US4358440 A1, 1982 ;
反应条件
sodium carbonate in water; N,N-dimethyl-formamide
1.5 h;
参考文献
Martinez, Jean; Laur, Janine; Castro, Bertrand
Tetrahedron, 1985 , vol. 41, # 4 p. 739 - 744
反应条件
sodium hydroxide in acetone
1.5 h;
参考文献
Masiukif.wicx, Elzbieta; Rzeszotarska, Barbara
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 11 p. 1672 - 1675
反应条件
sodium hydroxide in N,N-dimethyl-formamide
参考文献
Brinkman; Landi Jr.; Paterson Jr.; Stone
Synthetic Communications, 1991 , vol. 21, # 3 p. 459 - 465
反应条件
1: NMM / dimethylformamide / 0.17 h / -15 °C
2: NMM / dimethylformamide / 20 h / -20 °C
3: 90 percent / 1.5 N HCl/AcOH
4: 97 percent / HOBt*H2O, NEt3 / dimethylformamide / 23 h
5: 95 percent / 1.5 N HCl/AcOH / 1 h
6: 90 percent / HOBt*H2O, NEt3, DCC / dimethylformamide / a) -5 deg C to 0 deg C, 1 h, b) 20 deg C, 24 h
7: 86 percent / 0.5 M NaOH / acetone / 1.5 h
View Scheme
参考文献
Masiukif.wicx, Elzbieta; Rzeszotarska, Barbara
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 11 p. 1672 - 1675
反应条件
1: 90 percent / 1.5 N HCl/AcOH
2: 97 percent / HOBt*H2O, NEt3 / dimethylformamide / 23 h
3: 95 percent / 1.5 N HCl/AcOH / 1 h
4: 90 percent / HOBt*H2O, NEt3, DCC / dimethylformamide / a) -5 deg C to 0 deg C, 1 h, b) 20 deg C, 24 h
5: 86 percent / 0.5 M NaOH / acetone / 1.5 h
View Scheme
参考文献
Masiukif.wicx, Elzbieta; Rzeszotarska, Barbara
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 11 p. 1672 - 1675
反应条件
1: 95 percent / 1.5 N HCl/AcOH / 1 h
2: 90 percent / HOBt*H2O, NEt3, DCC / dimethylformamide / a) -5 deg C to 0 deg C, 1 h, b) 20 deg C, 24 h
3: 86 percent / 0.5 M NaOH / acetone / 1.5 h
View Scheme
参考文献
Masiukif.wicx, Elzbieta; Rzeszotarska, Barbara
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 11 p. 1672 - 1675
反应条件
1: NMM / dimethylformamide / 20 h / -20 °C
2: 90 percent / 1.5 N HCl/AcOH
3: 97 percent / HOBt*H2O, NEt3 / dimethylformamide / 23 h
4: 95 percent / 1.5 N HCl/AcOH / 1 h
5: 90 percent / HOBt*H2O, NEt3, DCC / dimethylformamide / a) -5 deg C to 0 deg C, 1 h, b) 20 deg C, 24 h
6: 86 percent / 0.5 M NaOH / acetone / 1.5 h
View Scheme
参考文献
Masiukif.wicx, Elzbieta; Rzeszotarska, Barbara
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 11 p. 1672 - 1675
