6-甲基-2-氧代-4-噻吩-2-基-1,2,3,4-四氢-嘧啶-5-羧酸乙酯合成路线 （共 10 条）
反应条件
1-methyl-3-(3-trimethoxysilylpropyl) imidazolium hydrogen sulfate immobilized on magnetic Fe3O4 nanoparticles in neat (no solvent)
T=100°C; Biginelli Pyrimidone Synthesis; 0.416667 h; Catalytic behavior;
参考文献
Safari, Javad; Zarnegar, Zohre
New Journal of Chemistry, 2014 , vol. 38, # 1 p. 358 - 365
反应条件
dodecatungstophosphoric acid/C in acetonitrile
T=80°C; Biginelli pyrimidine synthesis; 1.16667 h;
参考文献
Rafiee, Ezzat; Eavani, Sara; Babaee, Elaheh; Toodehroosta, Fatemeh; Daneshpazhuh, Kataun
Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 2008 , vol. 63, # 2 p. 178 - 182
反应条件
n-butyllithium in tetrahydrofuran
T=-40°C;
参考文献
Singh, Kamaljit; Arora, Divya; Singh, Sukhdeep
Tetrahedron Letters, 2007 , vol. 48, # 8 p. 1349 - 1352
反应条件
1: thiophene With n-butyllithium in tetrahydrofuran; hexanes
Inert atmosphere;
2: 6-methyl-2-oxo-1,2-dihydropyrimidine-5-carboxylic acid ethyl ester in tetrahydrofuran; hexanes
T=-40°C; Inert atmosphere;
参考文献
Singh, Kamaljit; Arora, Divya; Falkowski, Danielle; Liu, Qingxin; Moreland, Robert S.
European Journal of Organic Chemistry, 2009 , # 19 p. 3258 - 3264
反应条件
hydrogenchloride in tetrahydrofuran; methanol
6 h; Heating;
参考文献
Vanden Eynde, Jean Jacques; Audiart, Nancy; Canonne, Valerie; Michel, Sophie; Van Haverbeke, Yves; Oliver Kappe
Heterocycles, 1997 , vol. 45, # 10 p. 1967 - 1978
反应条件
1: thiophene-2-methanol With Bi(NO3)3 in acetonitrile
Heating;
2: ethyl acetoacetate; urea in acetonitrile
Heating;
参考文献
Khosropour, Ahmad R.; Khodaei, Mohammd M.; Beygzadch, Mojtaba; Jokar, Mahbubeh
Heterocycles, 2005 , vol. 65, # 4 p. 767 - 773
反应条件
1: 75 percent / nitric acid / 0.5 h / 0 - 20 °C
2: 40 percent / n-BuLi / tetrahydrofuran / -40 °C
View Scheme
参考文献
Singh, Kamaljit; Arora, Divya; Singh, Sukhdeep
Tetrahedron Letters, 2007 , vol. 48, # 8 p. 1349 - 1352
反应条件
1: 65 percent / NaHCO3 / dimethylformamide / 3 h / 70 °C
2: 60 percent / 3 N HCl / tetrahydrofuran; methanol / 6 h / Heating
View Scheme
参考文献
Vanden Eynde, Jean Jacques; Audiart, Nancy; Canonne, Valerie; Michel, Sophie; Van Haverbeke, Yves; Oliver Kappe
Heterocycles, 1997 , vol. 45, # 10 p. 1967 - 1978
反应条件
1: 65 percent / NaHCO3 / dimethylformamide / 3 h / 70 °C
2: 60 percent / 3 N HCl / tetrahydrofuran; methanol / 6 h / Heating
View Scheme
参考文献
Vanden Eynde, Jean Jacques; Audiart, Nancy; Canonne, Valerie; Michel, Sophie; Van Haverbeke, Yves; Oliver Kappe
Heterocycles, 1997 , vol. 45, # 10 p. 1967 - 1978
反应条件
bromine in chloroform
参考文献
Zigeuner,G.; Knopp,C.
Monatshefte fuer Chemie, 1970 , vol. 101, p. 1541 - 1546
