8-氯-6-(2-氟苯基)-1-甲基-4H-咪唑并[1,5-a][1,4]苯并二氮杂卓-3-羧酸合成路线 （共 4 条）
反应条件
in 1-methyl-pyrrolidin-2-one T=200°C; 0.25 h; Microreactor;
参考文献
F.I.S. Fabbrica Italiana Sintetici S.p.A.
Patent: EP2397470 A1, 2011 ;
Location in patent: Page/Page column 11 ;
反应条件
1: hydrogenchloride; water / ethanol / 3 h / 20 °C 2: 1-methyl-pyrrolidin-2-one / 0.5 h / 200 °C / Microreactor View Scheme
参考文献
F.I.S. Fabbrica Italiana Sintetici S.p.A.
Patent: EP2397470 A1, 2011 ;
反应条件
1: hydrogenchloride; water / ethanol / 3 h / 20 °C 2: 1-methyl-pyrrolidin-2-one / 0.5 h / 200 °C / Microreactor 3: ethanol / -15 - 30 °C / Inert atmosphere View Scheme
参考文献
F.I.S. Fabbrica Italiana Sintetici S.p.A.
Patent: EP2397470 A1, 2011 ;
反应条件
potassium hydroxide in methanol; water
参考文献
Hoffmann-La Roche Inc.
Patent: US4280957 A1, 1981 ;
