8-氯-3A,4-二氢-6-(2-氟苯基)-1-甲基-3H-咪唑[1,5-A][1,4]苯并二氮杂卓合成路线 （共 4 条）
反应条件
PPA in methanol; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; dichloromethane
反应条件
PPA; acetic anhydride in methanol; dichloromethane; water
反应条件
1: 2-aminomethyl-7-chloro-2,3-dihydro-5-(2-fluorophenyl)-1H-1,4-benzodiazepine dimaleate With ammonia in water; toluene 1 h; 2: 1,1,1-triethoxyethane in toluene 4 h; Heating / reflux;
参考文献
US2009/69306 A1, ;
Page/Page column 5-6 ;
反应条件
manganese(IV) oxide in toluene 2 h; Heating / reflux;
参考文献
CHEMAGIS LTD.
Patent: US2009/69306 A1, 2009 ;
Location in patent: Page/Page column 5-6 ;
