2,3,4,5-四氢-1H-1,4-苯二氮合成路线 （共 20 条）
反应条件
iron in ethanol T=40 - 45°C; 4.5 h;
参考文献
Topharman Shanghai Co., Ltd.; Weifang Tehua Chemical Co., Ltd.
Patent: EP2163538 A1, 2010 ;
Location in patent: Page/Page column 7 ;
反应条件
ethanol; iron T=40 - 45°C;
参考文献
TOPHARMAN SHANGHAI CO., LTD.; WEIFANG TEHUA CHEMICAL CO., LTD.
Patent: US2010/256358 A1, 2010 ;
Location in patent: Page/Page column 4-5 ;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 6 h; Heating;
参考文献
Sashida, Haruki; Fujii, Akira; Tsuchiya, Takashi
Chemical & Pharmaceutical Bulletin, 1987 , vol. 35, # 8 p. 3182 - 3189
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 1 h; Heating;
参考文献
Sashida, Haruki; Fujii, Akira; Tsuchiya, Takashi
Chemical & Pharmaceutical Bulletin, 1987 , vol. 35, # 10 p. 4110 - 4116
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 1 h; Heating;
参考文献
Sashida, Haruki; Fujii, Akira; Tsuchiya, Takashi
Chemical & Pharmaceutical Bulletin, 1987 , vol. 35, # 10 p. 4110 - 4116
反应条件
lithium aluminium tetrahydride in tetrahydrofuran Reduction; 18 h; Heating;
参考文献
Journal of Medicinal Chemistry, , vol. 42, # 25 p. 5241 - 5253
反应条件
1: pyridine / 24 h / Heating 2: acetic acid / 24 h 3: lithium aluminum hydride / tetrahydrofuran / 24 h View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 10 p. 2603 - 2607
反应条件
1: acetic acid / 24 h 2: lithium aluminum hydride / tetrahydrofuran / 24 h View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 10 p. 2603 - 2607
反应条件
1: 1.) sodium nitrite, 10percent HCl; 2.) sodium azide / 1.) water, 0 - 5 deg C, 1 h; 2.) water, room temp., 1 h 2: 38 percent / methanol; dioxane / 0.5 h / Irradiation 3: 98 percent / LiAlH4 / tetrahydrofuran / 1 h / Ambient temperature 4: 90 percent / LiAlH4 / tetrahydrofuran / 1 h / Heating View Scheme
参考文献
Chemical & Pharmaceutical Bulletin, , vol. 35, # 10 p. 4110 - 4116
反应条件
1: 38 percent / methanol; dioxane / 0.5 h / Irradiation 2: 98 percent / LiAlH4 / tetrahydrofuran / 1 h / Ambient temperature 3: 90 percent / LiAlH4 / tetrahydrofuran / 1 h / Heating View Scheme
参考文献
Chemical & Pharmaceutical Bulletin, , vol. 35, # 10 p. 4110 - 4116
