1,4-二甲基哌嗪-2,3-二酮合成路线 （共 13 条）
反应条件
in diethyl ether T=20°C;
参考文献
GEORGIA TECH RESEARCH CORPORATION
Patent: WO2005/123754 A2, 2005 ;
Location in patent: Page/Page column 45-46; Sheet 19 ;
反应条件
in diethyl ether T=25°C; 12 h;
参考文献
Takada, Yoshiaki; Nomura, Kenichi; Matsubara, Seijiro
Organic Letters, 2010 , vol. 12, # 22 p. 5204 - 5205
反应条件
water in ethanol 0.0833333 h; Heating;
参考文献
Journal of Organic Chemistry, , vol. 50, # 25 p. 5123 - 5127
反应条件
Lawesson's reagent in toluene Reflux;
参考文献
Pilia, Luca; Artizzu, Flavia; Espa, Davide; Marchio, Luciano; Mercuri, Maria Laura; Serpe, Angela; Deplano, Paola
Dalton Transactions, 2010 , vol. 39, # 35 p. 8139 - 8142
反应条件
n-butyllithium in tetrahydrofuran; hexane T=-78 - 20°C; 1 h;
参考文献
Journal of Organic Chemistry, , vol. 59, # 17 p. 4988 - 4992
反应条件
1: 4-bromo-N,N-dimethyl-aniline With n-butyllithium in tetrahydrofuran; hexanes T=-78°C; 1 h; 2: N,N'-dimethyl-piperazine-2,3-dione in tetrahydrofuran; hexanes T=-78 - 20°C; 2 h; 3: With hydrogenchloride in tetrahydrofuran; hexanes; water
参考文献
GEORGIA TECH RESEARCH CORPORATION
Patent: WO2005/123754 A2, 2005 ;
Location in patent: Page/Page column 46; Sheet 21 ;
参考文献
Shearer, Jason M.; Rokita, Steven E.
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 3 p. 501 - 504
反应条件
1: 1-trifluoromethyl-4-bromobenzene With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 1 h;
2: N,N'-dimethyl-piperazine-2,3-dione in tetrahydrofuran; hexane
T=-78 - 20°C; 72 h; Inert atmosphereEnzymatic reaction;
参考文献
Schulz, Gisela L.; Mastalerz, Michael; Ma, Chang-Qi; Wienk, Martijn; Janssen, Rene; Baeuerle, Peter
Macromolecules, 2013 , vol. 46, # 6 p. 2141 - 2151
反应条件
1: 1-bromo-4-(1,1-dimethylethyl)benzene With n-butyllithium in tetrahydrofuran; hexane
T=-50°C; 1 h;
2: N,N'-dimethyl-piperazine-2,3-dione in tetrahydrofuran; hexane
T=20°C; 1 h;
3: With hydrogenchloride in tetrahydrofuran; hexane
0.5 h;
参考文献
Sadhukhan, Subir K.; Viala, Christine; Gourdon, Andre
Synthesis, 2003 , # 10 p. 1521 - 1525
反应条件
Lawesson's reagent in toluene
T=100°C; 12 h;
参考文献
Isaksson, Roland; Liljefors, Tommy; Sandstroem, Jan
Journal of Chemical Research, Miniprint, 1981 , # 2 p. 664 - 700
