2-甲基-3-硝基苯甲酸甲酯合成路线 （共 49 条）
反应条件
1: 67 percent / DMF, dimethyl acetal / dimethylformamide / 7 h / 110 - 120 °C 2: 59 percent / NH3 / ethanol / 20 h / Ambient temperature View Scheme
参考文献
Matsui; Sugiura; Nakai; Iguchi; Shigeoka; Takada; Odagaki; Nagao; Ushio; Ohmoto; Iwamura; Yamazaki; Arai; Kawamura
Journal of Medicinal Chemistry, 1992 , vol. 35, # 18 p. 3307 - 3319
反应条件
N-bromosuccinmide; dibenzoyl peroxide in tetrachloromethane
参考文献
Kumiai Chemical Industry Co., Ltd.; Ihara Chemical Industry Co., Ltd.
Patent: US5534481 A1, 1996 ;
反应条件
N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile in tetrachloromethane Reflux;
参考文献
Bayer Healthcare AG
Patent: US2010/10060 A1, 2010 ;
Location in patent: Page/Page column 19 ;
反应条件
N-bromosuccinmide; dibenzoyl peroxide in tetrachloromethane; cyclohexane
参考文献
E. I. Du Pont de Nemours and Company
Patent: US4521241 A1, 1985 ;
反应条件
in tetrachloromethane; ethyl acetate
参考文献
Shah, Jamshed H.; Conner, Barry P.; Swartz, Glenn M.; Hunsucker, Kimberly A.; Rougas, John; D'Amato, Robert J.; Pribluda, Victor; Treston, Anthony
Patent: US2003/139451 A1, 2003 ;
反应条件
1: NBS / CCl4 / Heating; Irradiation 2: Et3N / dimethylformamide / 80 °C View Scheme
参考文献
NATCO PHARMA LIMITED; KONAKANCHI, Durga prasad; GONGALLA, Buchappa; SIKHA, Kotayya babu; KANDASWAMY, Chandrasekar; ADIBHATLA, Kali Satya Bhujanga Rao; NANNAPANENI, Venkaiah Chowdary
Patent: WO2011/111053 A1, 2011 ;
参考文献
van Scherpenzeel
Recueil des Travaux Chimiques des Pays-Bas, 1901 , vol. 20, p. 169
反应条件
1: 93 percent / dimethylformamide / 8 h / 130 °C 2: 68 percent / H2 / 10percent Pd-C / benzene / 6.5 h / 2585.7 Torr 3: 87 percent / DIBAL / CH2Cl2; diethyl ether / 4 h / -78 °C View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 23 p. 3211 - 3218
反应条件
1: 93 percent / dimethylformamide / 8 h / 130 °C 2: 68 percent / H2 / 10percent Pd-C / benzene / 6.5 h / 2585.7 Torr 3: 87 percent / DIBAL / CH2Cl2; diethyl ether / 4 h / -78 °C 4: 68 percent / MnO2 / CH2Cl2 / Ambient temperature View Scheme
参考文献
Kozikowski; Ishida; Chen
Journal of Organic Chemistry, 1980 , vol. 45, # 16 p. 3350 - 3352
反应条件
1: absolute nitric acid 2: hydrochloric acid / im Druckrohr View Scheme
参考文献
van Scherpenzeel
Recueil des Travaux Chimiques des Pays-Bas, 1901 , vol. 20, p. 169
