4-甲基香豆素基-4,7,8,9-四-氧-乙酰基-α-D-唾液酸甲酯合成路线 （共 8 条）
反应条件
sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride in chloroform 0.5 h; Heating;
参考文献
Rothermel, Joerg; Faillard, Hans
Carbohydrate Research, 1990 , vol. 196, # 1 p. 29 - 40
反应条件
in N,N-dimethyl-formamide 15 h; Inert atmosphere;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 11 p. 3406 - 3410
反应条件
Ag2CO3; molecular sieve in acetonitrile 3 h; Ambient temperature;
参考文献
Baggett; Marsden
Carbohydrate research, 1982 , vol. 110, # 1 p. 11 - 18
反应条件
N-ethyl-N,N-diisopropylamine in acetonitrile 3 h; Ambient temperature;
参考文献
Synlett, , # 5 p. 479 - 482
反应条件
1: trifluoroacetic acid / dichloromethane / 2 h / 3 °C 2: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane; N,N-dimethyl-formamide / 2 h 3: acetic anhydride; acetic acid; hydrogenchloride / 48 h / 0 - 4 °C 4: N,N-dimethyl-formamide / 15 h / |Inert atmosphere View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 11 p. 3406 - 3410
反应条件
1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane; N,N-dimethyl-formamide / 2 h 2: acetic anhydride; acetic acid; hydrogenchloride / 48 h / 0 - 4 °C 3: N,N-dimethyl-formamide / 15 h / |Inert atmosphere View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 11 p. 3406 - 3410
反应条件
1: acetic anhydride; acetic acid; hydrogenchloride / 48 h / 0 - 4 °C 2: N,N-dimethyl-formamide / 15 h / |Inert atmosphere View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 11 p. 3406 - 3410
反应条件
hydrogenchloride; 3 A molecular sieve; acetyl chloride; silver carbonate 1.) 0 deg C, 5 h, 2.) CH3CN, 24 h, RT; Yield given. Multistep reaction;
参考文献
Liebigs Annalen der Chemie, , p. 519 - 526
