2-(2-硝基苯胺基)苯甲酸合成路线 （共 23 条）
反应条件
1: 90 percent / DVP-Fe, conc. HCl / aq. ethanol; H2O / 4 h / Heating 2: 83 percent / conc. H3PO4 / xylene / 12 h / 140 °C 3: 1.) KO-t-Bu / 1.) dioxane, reflux, 1 h, 2.) reflux, 4 h View Scheme
参考文献
Ruger; Rohnert; Lohmann
Pharmazie, 1990 , vol. 45, # 8 p. 555 - 559
反应条件
trichlorophosphate Behandeln des Reaktionsprodukts mit wss. Ammoniak;
参考文献
Albert; Gledhill
Journal of the Society of Chemical Industry, London, 1945 , vol. 64, p. 169,170
反应条件
1: With potassium carbonate; copper in pentan-1-ol
T=140°C; 3.5 h;
2: With hydrogenchloride; water
参考文献
MENARINI INTERNATIONAL OPERATIONS LUXEMBOURG S.A.
Patent: WO2006/97449 A1, 2006 ;
Location in patent: Page/Page column 8-9 ;
反应条件
1: With copper; potassium carbonate in N,N-dimethyl-formamide
Ullmann condensation; 12 h; RefluxLarge scale reaction;
2: With acetic acid in water; N,N-dimethyl-formamide
T=25°C; Large scale reaction;
参考文献
Kalhapure, Rahul S.; Patil, Bhushan P.; Jadhav, Mahantesh N.; Kawle, Laxmikant A.; Wagh, Sanjay B.
E-Journal of Chemistry, 2011 , vol. 8, # 4 p. 1747 - 1749
反应条件
copper; potassium carbonate in nitrobenzene
T=195°C; 8 h;
参考文献
Cortes Cortes; Munoz Islas; Martinez Garcia; Zepeda Romero
Journal of Heterocyclic Chemistry, 1996 , vol. 33, # 6 p. 1723 - 1726
反应条件
pyridine; copper; potassium carbonate in water
Ullmann-Goldberg reaction; 0.333333 h; sonication;
参考文献
Docampo Palacios, Maite L.; Pellon Comdom, Rolando F.
Synthetic Communications, 2003 , vol. 33, # 10 p. 1771 - 1775
反应条件
sodium acetate; anhydrous copper acetate in water
6 h; Heating;
参考文献
Girisha, Hanakere R.; Srinivasa, Gejjalagere R.; Gowda, D. Channe
Journal of Chemical Research, 2006 , # 5 p. 342 - 344
反应条件
1: hydrogenchloride / water / 2 h / |Reflux
2: potassium carbonate; copper(l) iodide / N,N-dimethyl-formamide / 4 h / 120 °C
View Scheme
参考文献
Yu, Yongguo; Wu, Jianbo; Lei, Fan; Chen, Lei; Wan, Weili; Hai, Li; Guan, Mei; Wu, Yong
Letters in Drug Design and Discovery, 2013 , vol. 10, # 4 p. 369 - 373
反应条件
1: nitric acid; sulfuric acid / 2 h / 70 °C
2: potassium permanganate; water / 8 h / |Reflux
3: palladium 10 on activated carbon / tetrahydrofuran / 24 h / 20 °C
4: sodium nitrite; hydrogenchloride; potassium iodide / dichloromethane / 4 h / 0 - 20 °C
5: potassium carbonate; copper(l) iodide / N,N-dimethyl-formamide / 4 h / 120 °C
View Scheme
参考文献
Yu, Yongguo; Wu, Jianbo; Lei, Fan; Chen, Lei; Wan, Weili; Hai, Li; Guan, Mei; Wu, Yong
Letters in Drug Design and Discovery, 2013 , vol. 10, # 4 p. 369 - 373
反应条件
1: potassium permanganate; water / 8 h / |Reflux
2: palladium 10 on activated carbon / tetrahydrofuran / 24 h / 20 °C
3: sodium nitrite; hydrogenchloride; potassium iodide / dichloromethane / 4 h / 0 - 20 °C
4: potassium carbonate; copper(l) iodide / N,N-dimethyl-formamide / 4 h / 120 °C
View Scheme
参考文献
Yu, Yongguo; Wu, Jianbo; Lei, Fan; Chen, Lei; Wan, Weili; Hai, Li; Guan, Mei; Wu, Yong
Letters in Drug Design and Discovery, 2013 , vol. 10, # 4 p. 369 - 373
