5-苯基吡唑-3-羧酸乙酯合成路线 （共 14 条）
反应条件
sodium hydroxide in 1,4-dioxane T=20°C; 18 h;
参考文献
Van Herk; Brussee; Van den Nieuwendijk; Van der Klein; IJzerman; Stannek; Burmeister; Lorenzen
Journal of Medicinal Chemistry, 2003 , vol. 46, # 18 p. 3945 - 3951
反应条件
lithium aluminium tetrahydride
参考文献
Jones et al.
Journal of Organic Chemistry, 1954 , vol. 19, p. 1428,1431
反应条件
NH2NH2•xH2O; acetic acid in ethanol
T=20°C; 5 h;
参考文献
Shionogi and Co., Ltd.; YUKIMASA, Akira
Patent: WO2012/144661 A1, 2012 ;
Location in patent: Page/Page column 80; 81 ;
WO 2012/144661 A1
反应条件
1: acetophenone N-ethoxycarbonylhydrazone With n-butyllithium in tetrahydrofuran; hexane
T=-78 - 20°C; 1 h;
2: oxalic acid diethyl ester in tetrahydrofuran; hexane
T=-78 - 20°C; 16 h;
3: With toluene-4-sulfonic acid in toluene
10 h; Heating; Further stages.;
参考文献
Dang, Tung T.; Dang, Tuan T.; Fischer, Christine; Goerls, Helmar; Langer, Peter
Tetrahedron, 2008 , vol. 64, # 9 p. 2207 - 2215
反应条件
in octane
T=110°C; 1 h;
参考文献
Padwa, Albert; Kulkarni, Yashwant S.; Zhang, Zhijia
Journal of Organic Chemistry, 1990 , vol. 55, # 13 p. 4144 - 4153
反应条件
1: EtONa / ethanol / 18 h / 20 °C
2: N2H4*H2O; AcOH / 8 h / Heating
View Scheme
参考文献
Van Herk; Brussee; Van den Nieuwendijk; Van der Klein; IJzerman; Stannek; Burmeister; Lorenzen
Journal of Medicinal Chemistry, 2003 , vol. 46, # 18 p. 3945 - 3951
反应条件
T=80°C; 48 h; Neat (no solvent);
参考文献
Vuluga, Daniela; Legros, Julien; Crousse, Benoit; Bonnet-Delpon, Daniele
Green Chemistry, 2009 , vol. 11, # 2 p. 156 - 159
反应条件
1: 1) n-BuLi / 1) ether, THF, -110 deg C, 2) -110 to -25 deg C
2: 58 percent / POCl3, pyridine / 1) 0 deg C, 6 h, 2) r.t., 12 h
3: 82 percent / octane / 1 h / 110 °C
View Scheme
参考文献
Padwa, Albert; Kulkarni, Yashwant S.; Zhang, Zhijia
Journal of Organic Chemistry, 1990 , vol. 55, # 13 p. 4144 - 4153
反应条件
1: 58 percent / POCl3, pyridine / 1) 0 deg C, 6 h, 2) r.t., 12 h
2: 82 percent / octane / 1 h / 110 °C
View Scheme
参考文献
Padwa, Albert; Kulkarni, Yashwant S.; Zhang, Zhijia
Journal of Organic Chemistry, 1990 , vol. 55, # 13 p. 4144 - 4153
反应条件
in benzene
96 h; Ambient temperature; Yields of byproduct given;
参考文献
Regitz, Manfred; Martin, Roland
Liebigs Annalen der Chemie, 1984 , # 10 p. 1641 - 1652
