反应条件
1.1: 1,4-dioxane / 110 °C 2.1: 2,6-dimethylpyridine / dichloromethane / 1 h / -78 - 20 °C 3.1: triethylamine; 1,3-bis-(diphenylphosphino)propane / palladium diacetate / N,N-dimethyl-formamide / Reflux 4.1: sulfuric acid / ethyl acetate / 2 h / 20 °C 5.1: hydrogenchloride; sodium nitrite / water / 0.5 h / -5 - 0 °C / Cooling with ice/alcohol 5.2: 0 - 20 °C 6.1: water; lithium iodide / pyridine / 30 h / 130 °C View Scheme
参考文献
Liang, Jun; Van Abbema, Anne; Balazs, Mercedesz; Barrett, Kathy; Berezhkovsky, Leo; Blair, Wade; Chang, Christine; Delarosa, Donnie; Devoss, Jason; Driscoll, Jim; Eigenbrot, Charles; Ghilardi, Nico; Gibbons, Paul; Halladay, Jason; Johnson, Adam; Kohli, Pawan Bir; Lai, Yingjie; Liu, Yanzhou; Lyssikatos, Joseph; Mantik, Priscilla; Menghrajani, Kapil; Murray, Jeremy; Peng, Ivan; Sambrone, Amy; Shia, Steven; Shin, Young; Smith, Jan; Sohn, Sue; Tsui, Vickie; Ultsch, Mark; Wu, Lawren C.; Xiao, Yisong; Yang, Wenqian; Young, Judy; Zhang, Birong; Zhu, Bing-Yan; Magnuson, Steven
Journal of Medicinal Chemistry, 2013 , vol. 56, # 11 p. 4521 - 4536