4-氯-2-氟-N-乙酰基苯胺合成路线 （共 10 条）
反应条件
in acetic acid T=20°C; 2 h;
参考文献
FLYNN, Daniel L.; KAUFMAN, Michael D.
Patent: WO2013/184119 A1, 2013 ;
Location in patent: Paragraph 0169 ;
反应条件
in acetic acid T=25°C; 2 h;
参考文献
Fujitsu Limited; KAMIYA, Nozomu; TOMONAGA, Atsushi; SUGIYAMA, Hajime
Patent: EP2647622 A1, 2013 ;
Location in patent: Paragraph 0137-0138 ;
反应条件
chlorine in acetic acid
反应条件
sulfuryl dichloride in 1,4-dioxane T=20°C; 24 h;
参考文献
Zhang, Chuan-Yu; Wang, Bao-Lei; Liu, Xing-Hai; Li, Yong-Hong; Wang, Su-Hua; Li, Zheng-Ming
Heterocyclic Communications, 2008 , vol. 14, # 6 p. 397 - 404
反应条件
triethylamine in tetrahydrofuran; ethanol
反应条件
chlorine in acetic acid
反应条件
1: phosphorus pentasulfide / benzene / 3 h / Heating 2: NaH / toluene / 0.5 h / Heating View Scheme
参考文献
Van Zandt, Michael C.; Jones, Michael L.; Gunn, David E.; Geraci, Leo S.; Jones, J. Howard; Sawicki, Diane R.; Sredy, Janet; Jacot, Jorge L.; DiCioccio, A. Thomas; Petrova, Tatiana; Mitschler, Andre; Podjarny, Alberto D.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 9 p. 3141 - 3152
反应条件
1: phosphorus pentasulfide / benzene / 3 h / Heating 2: NaH / toluene / 0.5 h / Heating 3: aq. NaOH / ethane-1,2-diol / 3 h / 125 °C View Scheme
参考文献
Van Zandt, Michael C.; Jones, Michael L.; Gunn, David E.; Geraci, Leo S.; Jones, J. Howard; Sawicki, Diane R.; Sredy, Janet; Jacot, Jorge L.; DiCioccio, A. Thomas; Petrova, Tatiana; Mitschler, Andre; Podjarny, Alberto D.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 9 p. 3141 - 3152
反应条件
sodium hydroxide; water in ethanol 3 h; Reflux;
参考文献
Zhang, Chuan-Yu; Wang, Bao-Lei; Liu, Xing-Hai; Li, Yong-Hong; Wang, Su-Hua; Li, Zheng-Ming
Heterocyclic Communications, 2008 , vol. 14, # 6 p. 397 - 404
反应条件
hydrogenchloride in methanol; sodium hydroxide; ethanol; dichloromethane; acetic acid
参考文献
E. I. Du Pont de Nemours and Company
Patent: US4120693 A1, 1978 ;
