5-脱氧-L-阿拉伯糖苯基腙合成路线 （共 9 条）
反应条件
1: 2) K4<Fe(CN)6>, KI, 30percent H2O2 / 1) aq. CH3OH, 2 h, RT; 1 h, reflux, 2) 15 h 2: 57 percent / acetonitrile / 72 h / Ambient temperature 3: 57 percent / 1N NH3 / 12 h / Ambient temperature View Scheme
参考文献
Kappel, Mathias; Mengel, Rolf; Pfleiderer, Wolfgang
Liebigs Annalen der Chemie, 1984 , # 11 p. 1815 - 1825
反应条件
1: 2.) K3Fe(CN)6, KI, O2, HCOOH / 1.) methanol, a.) 25 deg C, 90 min., b.) reflux, 30 min., 2.) methanol, water, 25 deg C, 20 h 2: 90 mg / CH3COONH4, 28percent aq. NH3 / 4 h / Heating View Scheme
参考文献
Schircks, Bernhard; Bieri, Jost H.; Viscontini, Max
Helvetica Chimica Acta, 1985 , vol. 68, p. 1639 - 1643
反应条件
dihydrogen peroxide; potassium iodide; potassium hexacyano-ferrate 1) aq. CH3OH, 2 h, RT; 1 h, reflux, 2) 15 h; Yield given. Multistep reaction;
参考文献
Kappel, Mathias; Mengel, Rolf; Pfleiderer, Wolfgang
Liebigs Annalen der Chemie, 1984 , # 11 p. 1815 - 1825
反应条件
Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Armarego, Wilfred L. F.; Waring, Paul; Paal, Bela
Australian Journal of Chemistry, 1982 , vol. 35, # 4 p. 785 - 793
反应条件
<b>Multi-step reaction with 3 steps<br /> </b>1: sodium tetrahydroborate / dimethyl sulfoxide / 2.5 h / 20 °C<br />2: hydrochlorid acid; water / dimethyl sulfoxide / 5 h / 20 °C<br />3: acetic acid / methanol / 1 h / 20 °C<br /> <br />
参考文献
CELLIXBIO PRIVATE LIMITED; Kandula, Mahesh Patent: US2015/291590 A1, 2015 ;
反应条件
<b>Multi-step reaction with 2 steps<br /> </b>1: hydrochlorid acid; water / dimethyl sulfoxide / 5 h / 20 °C<br />2: acetic acid / methanol / 1 h / 20 °C<br /> <br />
参考文献
CELLIXBIO PRIVATE LIMITED; Kandula, Mahesh Patent: US2015/291590 A1, 2015 ;
反应条件
<b>With</b> <a href="#" onclick="return RXDsubstances(event, this, '506007', constants.ctx, '0')">acetic acid</a> <b>in</b> <a href="#" onclick="return RXDsubstances(event, this, '1098229', constants.ctx, '0')">methanol</a> <br />T=20°C; 1 h; <br /> <br />
参考文献
CELLIXBIO PRIVATE LIMITED; Kandula, Mahesh Patent: US2015/291590 A1, 2015 ; Location in patent: Paragraph 0168; 0177; 0178 ;
反应条件
<b>Multi-step reaction with 2 steps<br /> </b>1: ammonium hydroxide / water / 14 h / 22 °C / pH 9 - 10 / yellow light<br />2: methanol / 1 h / 20 °C / yellow light<br /> <br />
参考文献
KANEKA CORPORATION Patent: US2011/218339 A1, 2011 ;
反应条件
<b>Multi-step reaction with 5 steps<br /> </b>1.1: hydrochlorid acid / water / 0 °C<br />1.2: 1 h<br />2.1: pyridine / -5 - 20 °C<br />3.1: sodium tetrahydroborate / dimethyl sulfoxide / 2.5 h / 20 °C<br />4.1: hydrochlorid acid; water / dimethyl sulfoxide / 5 h / 20 °C<br />5.1: acetic acid / methanol / 1 h / 20 °C<br /> <br />
参考文献
CELLIXBIO PRIVATE LIMITED; Kandula, Mahesh Patent: US2015/291590 A1, 2015 ;
