2-氨基-4-甲氧基-苯甲醛合成路线 （共 4 条）
反应条件
hydrogenchloride; iron; acetic acid in ethanol; water
T=60 - 65°C; 1 h;
参考文献
NOVARTIS VACCINES and DIAGNOSTICS, INC.
Patent: WO2007/117607 A2, 2007 ;
Location in patent: Page/Page column 310 ;
反应条件
manganese(IV) oxide in dichloromethane
T=20°C; 23 h; Inert atmosphere;
参考文献
Ida, Yoshihiro; Matsubara, Ayaka; Nemoto, Toru; Saito, Manabu; Hirayama, Shigeto; Fujii, Hideaki; Nagase, Hiroshi
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 19 p. 5810 - 5831
反应条件
1: borane-THF / tetrahydrofuran / 1.67 h / 0 - 20 °C / |Inert atmosphere
2: manganese(IV) oxide / dichloromethane / 23 h / 20 °C / |Inert atmosphere
View Scheme
参考文献
Ida, Yoshihiro; Matsubara, Ayaka; Nemoto, Toru; Saito, Manabu; Hirayama, Shigeto; Fujii, Hideaki; Nagase, Hiroshi
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 19 p. 5810 - 5831
反应条件
1: N-bromosuccinmide / dichloromethane
2: neat (no solvent) / 2 h / 180 °C
3: trichlorophosphate / 5 h / 130 °C
View Scheme
参考文献
BLUEPRINT MEDICINES; BIFULCO, Neil, Jr.; BROOIJMANS, Natasja; HODOUS, Brian, L.; KIM, Joseph, L.; MIDUTURU, Chandrasekhar, V.
Patent: WO2014/11900 A2, 2014 ;
