N-叔丁氧羰基-蛋氨酰-天冬氨酰-苯丙氨酰胺合成路线 （共 4 条）
反应条件
4-methyl-morpholine in N,N-dimethyl-formamide
40 h; Ambient temperature;
参考文献
Sakina; Kawazura; Morihara; Yajima
Chemical and Pharmaceutical Bulletin, 1988 , vol. 36, # 10 p. 3915 - 3919
反应条件
1: 85 percent / Et3N / dimethylformamide / 16 h
2: 83 percent / H2 / Pd / dimethylformamide; H2O
3: 85 percent / N-methylmorpholine / dimethylformamide / 40 h / Ambient temperature
View Scheme
参考文献
Sakina; Kawazura; Morihara; Yajima
Chemical and Pharmaceutical Bulletin, 1988 , vol. 36, # 10 p. 3915 - 3919
反应条件
N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide
20 h; Ambient temperature; Yield given;
参考文献
Cerovsky, Vaclav; Pirkova, Jana; Majer, Pavel; Slaninova, Jirina; Hlavacek, Jan
Collection of Czechoslovak Chemical Communications, 1990 , vol. 55, # 7 p. 1873 - 1882
反应条件
triethylamine
1.) DMF, -10 deg C, 2.) 20 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Sadovnikova, N. V.; Fedotov, V. P.; Shvachkin, Yu. P.; Shishkina, A. A.; Kolomeitseva, L. A.
Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 12 p. 838 - 842
Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 12 p. 1424 - 1427
