乙基 2-(乙酰基氨基)-4,5,6,7-四氢-1-苯并噻吩-3-羧酸合成路线 （共 8 条）
反应条件
4-(N,N-dimethlyamino)pyridine in tetrahydrofuran T=20°C; 2 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2003/104219 A1, 2003 ;
Location in patent: Page 10; 12 ;
WO 03/104219 A1
参考文献
Aurelio, Luigi; Flynn, Bernard L.; Scammells, Peter J.
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 13 p. 4886 - 4902
反应条件
diatomic sulphur; phthalic acid dimethyl ester T=195°C; 8 h;
参考文献
BAYER PHARMACEUTICALS CORPORATION
Patent: WO2006/44524 A1, 2006 ;
Location in patent: Page/Page column 54-55 ;
WO 2006/044524 A1
反应条件
sodium hydroxide; water in ethanol T=80°C; 2 h;
参考文献
SYNGENTA PARTICIPATIONS AG; SYNGENTA LIMITED
Patent: WO2005/44008 A2, 2005 ;
Location in patent: Page/Page column 130 ;
反应条件
1: 64.9 percent / K2Cr2O7 / aq. acetic acid / 1. 65-80 deg C; 2. 20 deg C, 2 h
2: 83 percent / sodium methylate / methanol / 1 h / 20 °C
View Scheme
参考文献
Kharizomenova, I. A.; Kapustina, M. V.; Grinev, A. N.; Sheinker, Yu. N.; Alekseeva, L. M.; Kuleshova, E. F.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1984 , vol. 20, # 12 p. 1339 - 1342
Khimiya Geterotsiklicheskikh Soedinenii, 1984 , # 12 p. 1626 - 1629
反应条件
1: 64.9 percent / K2Cr2O7 / aq. acetic acid / 1. 65-80 deg C; 2. 20 deg C, 2 h
2: 83 percent / sodium methylate / methanol / 1 h / 20 °C
3: 1. NaNO2, conc. HCl; 2. copper acetate / 1. dioxane, -7 to -10 deg C, 20 min; 2. dioxane, ethanol, 70 deg C, 30 min
4: 45.9 percent / NaOH; aq. HCl / ethanol / 0.33 h / Heating
View Scheme
参考文献
Kharizomenova, I. A.; Kapustina, M. V.; Grinev, A. N.; Sheinker, Yu. N.; Alekseeva, L. M.; Kuleshova, E. F.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1984 , vol. 20, # 12 p. 1339 - 1342
Khimiya Geterotsiklicheskikh Soedinenii, 1984 , # 12 p. 1626 - 1629
反应条件
hydrazine hydrate in ethanol
8 h; Heating;
参考文献
Perrissin; Favre; Luu Duc; Huguet; Gaultier; Narcisse
European Journal of Medicinal Chemistry, 1988 , vol. 23, # 5 p. 453 - 456
