甲基5-甲酰基-1H-吡咯-3-羧酸酯合成路线 （共 5 条）
反应条件
palladium on activated charcoal T=210°C;
参考文献
Anderson, Hugh J.; Loader, Charles E.; Foster, Aidan
Canadian Journal of Chemistry, 1980 , vol. 58, p. 2527 - 2530
反应条件
1: N,N-dimethylpyrrole-2-formiminium chloride; 2,2,2-trichloroacetyl chloride With AlCl3, aluminium chloride in 1,2-dichloro-ethane
4 h; RefluxInert atmosphere;
2: methanol With sodium methylate in 1,2-dichloro-ethane
T=20°C; 2 h; Inert atmosphere;
参考文献
Millennium Pharmaceuticals, Inc.
Patent: US2011/213003 A1, 2011 ;
Location in patent: Page/Page column 75 ;
US 20110213003 A1
反应条件
formic acid; nickel monoaluminide in (2S)-N-methyl-1-phenylpropan-2-amine hydrate
参考文献
Schering Aktiengesellschaft
Patent: US4466976 A1, 1984 ;
反应条件
disodium hydrogenphosphate; sodium amalgam in methanol
T=20°C; desulfonylation; 3 h;
参考文献
Minguez, Jose M.; Vaquero, Juan J.; Alvarez-Builla, Julio; Castano, Obis; Andres, Jose L.
Journal of Organic Chemistry, 1999 , vol. 64, # 21 p. 7788 - 7801
反应条件
1: n-butyllithium / 1.) THF, -78 deg C, 0.5 h.
2: aqueous sodium hydrogen carbonate / Heating
View Scheme
参考文献
Muchowski, Joseph M.; Hess, Petr
Tetrahedron Letters, 1988 , vol. 29, # 26 p. 3215 - 3218
