1-(2-硝基苯基)哌嗪合成路线 （共 15 条）
反应条件
sodium carbonate; triethylamine in methanol; n-heptane; dimethyl sulfoxide; ethyl acetate; toluene
反应条件
T=100°C; Substitution; 10 h;
参考文献
Synaptic Pharmaceutical Corporation
Patent: US6245773 B1, 2001 ;
US 6245773 B1
参考文献
Helvetica Chimica Acta, , vol. 39, p. 1144,1154
反应条件
hydrogenchloride in acetonitrile Yield given;
参考文献
Tetrahedron Letters, , vol. 38, # 23 p. 4091 - 4094
反应条件
potassium carbonate in dimethyl sulfoxide T=100°C; Arylation; 12 h; Product distribution; Further Variations:SolventsTemperatures;
参考文献
Tetrahedron Letters, , vol. 40, # 31 p. 5661 - 5665
反应条件
1: CHCl3 2: palladium/charcoal; ethanol / 36775.4 Torr / Hydrogenation View Scheme
参考文献
Schmutz; Kuenzle
Helvetica Chimica Acta, 1956 , vol. 39, p. 1144,1154
反应条件
potassium carbonate in butanone T=80°C; 24 h;
参考文献
Sukalovic, Vladimir; Zlatovic, Mario; Andric, Deana; Roglic, Goran; Kostic-Rajacic, Sladjana; Soskic, Vukic
Arzneimittel-Forschung/Drug Research, 2005 , vol. 55, # 3 p. 145 - 152
反应条件
potassium carbonate in N,N-dimethyl-formamide
参考文献
Elliott; Broughton; Cascieri; Chicchi; Huscroft; Kurtz; MacLeod; Sadowski; Stevenson
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 14 p. 1851 - 1856
反应条件
1: K2CO3 / dimethylformamide 2: SnCl2 / ethanol View Scheme
参考文献
Elliott; Broughton; Cascieri; Chicchi; Huscroft; Kurtz; MacLeod; Sadowski; Stevenson
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 14 p. 1851 - 1856
反应条件
hydrogen; acetic acid; palladium on activated charcoal in methanol; ethyl acetate P=760.051 Torr;
参考文献
Patch, Raymond J.; Brandt, Benjamin M.; Asgari, Davoud; Baindur, Nand; Chadha, Naresh K.; Georgiadis, Taxiarchis; Cheung, Wing S.; Petrounia, Ioanna P.; Donatelli, Robert R.; Chaikin, Margery A.; Player, Mark R.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 22 p. 6070 - 6074
