4-氯-1-乙基-1H-吡唑[3,4-b]吡啶-5-羧酸合成路线 （共 4 条）
反应条件
1: With potassium hydroxide; water in 1,4-dioxane
T=20°C; 16 h;
2: With hydrogenchloride; water in 1,4-dioxane
T=0°C; pH=3; 0.5 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2005/90353 A1, 2005 ;
Location in patent: Page/Page column 81-82 ;
WO 2005/090353 A1
反应条件
1.1: trichlorophosphate / 8 h / 135 °C
1.2: 0 °C / pH 7
2.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 2 h / 35 °C
2.2: 20 °C / pH 4
View Scheme
参考文献
Jablonski, Philippe; Nettekoven, Matthias; Patiny-Adam, Angëlique; Ratni, Hasane; Stadler, Heinz
Patent: US2011/257402 A1, 2011 ;
US 20110257402 A1
反应条件
1.1: 4 h / 120 °C
2.1: trichlorophosphate / 8 h / 135 °C
2.2: 0 °C / pH 7
3.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 2 h / 35 °C
3.2: 20 °C / pH 4
View Scheme
参考文献
Jablonski, Philippe; Nettekoven, Matthias; Patiny-Adam, Angëlique; Ratni, Hasane; Stadler, Heinz
Patent: US2011/257402 A1, 2011 ;
US 20110257402 A1
反应条件
thionyl chloride
1 h; Heating / reflux;
参考文献
GLAXO GROUP LIMITED
Patent: WO2005/90352 A1, 2005 ;
Location in patent: Page/Page column 62 ;
WO 2005/090352 A1
