1-溴-4-(二氟甲氧基)苯合成路线 （共 17 条）
反应条件
sodium hydroxide in hexane; 1-chloro-1,1-difluoro-methane; water; ethyl acetate; acetone
参考文献
BRISTOL-MYERS SQUIBB COMPANY
Patent: EP768305 A1, 1997 ;
EP 0768305 A1
反应条件
1: 4-bromo-phenol With potassium hydroxide in water; acetonitrile T=0°C; 0.0833333 h; 2: (EtO)2P(O)CF2Br in water; acetonitrile T=0 - 20°C;
参考文献
US2012/329802 A1, ;
Page/Page column 32-33 ;
反应条件
potassium hydroxide in acetonitrile T=50°C;
参考文献
Zheng, Ji; Li, Ya; Zhang, Laijun; Hu, Jinbo; Meuzelaar, Gerrit Joost; Federsel, Hans-Juergen
Chemical Communications, 2007 , # 48 p. 5149 - 5151
反应条件
potassium hydroxide in acetonitrile T=80°C; 4 h;
参考文献
Zhang, Laijun; Zheng, Ji; Hu, Jinbo
Journal of Organic Chemistry, 2006 , vol. 71, # 26 p. 9845 - 9848
反应条件
sodium hydroxide in isopropyl alcohol T=65 - 75°C; 6 h;
参考文献
Shelyazhenko, S. V.; Fialkov, Yu. A.; Yagupol'skii, L. M.
Journal of Organic Chemistry USSR (English Translation), 1992 , vol. 28, # 8.1 p. 1317 - 1324
Zhurnal Organicheskoi Khimii, 1992 , vol. 28, # 8 p. 1652 - 1660
反应条件
difluoro[4-(trifluoromethyl)phenyl]-λ(3)-bromane in chloroform T=20°C; 2 h; Inert atmosphere;
参考文献
Ochiai, Masahito; Yoshimura, Akira; Hoque, Md. Mahbubul; Okubo, Takuji; Saito, Motomichi; Miyamoto, Kazunori
Organic Letters, 2011 , vol. 13, # 20 p. 5568 - 5571
反应条件
1: 4-bromo-phenol With water; potassium hydroxide P=760.051 Torr; 0.5 h; Inert atmosphere; 2: trifluoromethane acid in 1,4-dioxane T=50°C; P=760.051 Torr; Inert atmosphere; Reagent/catalystSolventTemperature;
参考文献
Thomoson, Charles S.; Dolbier, William R.
Journal of Organic Chemistry, 2013 , vol. 78, # 17 p. 8904 - 8908
反应条件
1: p-bromophenyl mercaptan With water-d2; potassium hydroxide P=760.051 Torr; 0.5 h; Inert atmosphere; 2: trifluoromethane acid in 1,4-dioxane T=50°C; P=760.051 Torr; Inert atmosphere;
参考文献
Journal of Organic Chemistry, , vol. 78, # 17 p. 8904 - 8908
反应条件
1: With sodium hydroxide in water 0.0833333 h; Inert atmosphere; 2: With 1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo-[2.2.2]octane bis(tetrafluoroborate) in water 1 h; Inert atmosphereUV-irradiation;
参考文献
Leung, Joe C. T.; Chatalova-Sazepin, Claire; West, Julian G.; Rueda-Becerril, Montserrat; Paquin, Jean-Francois; Sammis, Glenn M.
Angewandte Chemie - International Edition, 2012 , vol. 51, # 43 p. 10804 - 10807
Angewandte Chemie, 2012 , vol. 124, # 43 p. 10962 - 10965
反应条件
potassium carbonate in water; N,N-dimethyl-formamide T=100°C;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 13 p. 3857 - 3863
