(S)-1-(吡啶-2-基)乙醇合成路线 （共 24 条）
反应条件
anhydrous magnesium perchlorate; polymer-bound NADH (2a) in acetonitrile; benzene T=80°C; 120 h; Further byproducts given;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2005/61465 A1, 2005 ;
Location in patent: Page/Page column 64 ;
WO 2005/061465 A1
反应条件
C7H7O3PolS; sodium cyanoborohydride; ammonium chloride in methanol T=25°C; 65 h; Polystyrene;
参考文献
WO2005/49033 A1, ;
Page/Page column 98 ;
WO 2005/049033 A1
反应条件
in diethyl ether T=0°C; 2 h;
参考文献
Uenishi, Jun'ichi; Hiraoka, Takao; Hata, Shinichiro; Nishiwaki, Kenji; Yonemitsu, Osamu; Nakamura, Kaoru; Tsukube, Hiroshi
Journal of Organic Chemistry, 1998 , vol. 63, # 8 p. 2481 - 2487
反应条件
1: 2-bromo-pyridine With isopropylmagnesium chloride in tetrahydrofuran T=20°C; Grignard reaction; 2 h; 2: acetaldehyde T=20°C; Alkylation; 2 h;
参考文献
Trecourt, Francois; Breton, Gilles; Bonnet, Veronique; Mongin, Florence; Marsais, Francis; Queguiner, Guy
Tetrahedron, 2000 , vol. 56, # 10 p. 1349 - 1360
反应条件
sulfuric acid in water T=95°C; 48 h;
参考文献
Jones, Gurnos; Mouat, Deborah J.; Tonkinson, Daryl J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 2719 - 2724
反应条件
nicotinamide; sodium phosphate buffer; G6P; NADP; magnesium chloride in water T=37°C; 1 h; biotransformation with phenobarbital-pretreated rat-liver (S-9);
参考文献
Heterocycles, , vol. 42, # 2 p. 831 - 836
反应条件
sodium hydroxide; RuCl2(PPh3)(iBu-BTP) T=82°C; P=750.075 Torr; 24 h;
参考文献
Yu; Zeng; Sun; Deng; Dong; Chen; Wang; Pei
Journal of Organometallic Chemistry, 2007 , vol. 692, # 11 p. 2306 - 2313
反应条件
palladium 10 on activated carbon; zinc in ethanol; water T=150°C; 24 h; Autoclave;
参考文献
Arkivoc, , vol. 2014, # 2 p. 175 - 186
反应条件
magnesium in tetrahydrofuran T=20°C;
参考文献
Journal of Medicinal Chemistry, , vol. 51, # 22 p. 7193 - 7204
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran; dichloromethane 20 h; Ambient temperature;
参考文献
Andrews, Ian P.; Lewis, Norman J.; McKillop, Alexander; Wells, Andrew S.
Heterocycles, 1996 , vol. 43, # 6 p. 1151 - 1158
