反应条件
1: 1.) lithium hexamethyldisilazide (LiHMDS) / 1.) hexane, THF, -78 deg C, 10 min, 2.) 15 min 2: 79 percent / triphenylphosphine, diethyl azodicarboxylate (DEAD), diphenylphosphoryl azide (DPPA) / tetrahydrofuran / 48 h / 20 °C 3: 59 percent / HCl / 10 h / Heating 4: 91 percent / lithium hydroxide / tetrahydrofuran; H2O / 1 h / 0 °C 5: 68 percent / 3-hydroxybenzotriazole (HOBT), dicyclohexylcarbodiimide (DCC), triethylamine / tetrahydrofuran / 12 h 6: 86 percent / H2 / 5percent Pd/C / methanol / 48 h / 760 Torr View Scheme
参考文献
Journal of Organic Chemistry, , vol. 54, # 17 p. 4235 - 4237
