1-(2,4-二氯l苯基)-2-(1H-1,2,4-噻唑-1-基)-乙酮合成路线 （共 25 条）
反应条件
trifluorormethanesulfonic acid in toluene T=25°C; 60 h;
参考文献
Oh, Keimei; Yamada, Kazuhiro; Yoshizawa, Yuko
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 24 p. 6915 - 6919
反应条件
potassium carbonate in acetonitrile
T=85°C; 0.833333 h; microwave irradiation;
参考文献
Lebouvier, Nicolas; Giraud, Francis; Corbin, Typhanie; Na, Young Min; Le Baut, Guillaume; Marchand, Pascal; Le Borgne, Marc
Tetrahedron Letters, 2006 , vol. 47, # 36 p. 6479 - 6483
反应条件
in N,N-dimethyl-formamide
T=0°C; 2 h;
参考文献
Baji, H.; Flammang, M.; Kimny, T.; Gasquez, F.; Compagnon, P. L.; Delcourt, A.
European Journal of Medicinal Chemistry, 1995 , vol. 30, # 7-8 p. 617 - 626
反应条件
hydrogenchloride; sodium nitrite
T=0 - 20°C;
参考文献
Astleford, Bret A.; Goe, Gerald L.; Keay, James G.; Scriven, Eric F. V.
Journal of Organic Chemistry, 1989 , vol. 54, # 3 p. 731 - 732
参考文献
Bayer Aktiengesellschaft
Patent: US4293715 A1, 1981 ;
反应条件
in para-xylene
T=200°C; 1 h; Microwave irradiation;
参考文献
Obermayer, David; Gutmann, Bernhard; Oliver Kappe
Angewandte Chemie - International Edition, 2009 , vol. 48, # 44 p. 8321 - 8324
反应条件
sulfuric acid; sodium nitrite in water
T=0 - 20°C;
参考文献
Krimer, M. Z.; Tashi, B. P.; Roitburd, G. V.; Shtirkov, I. M.; Manaev, S. A.; et al.
Doklady Chemistry, 1989 , vol. 308, # 4-6 p. 299 - 301
Dokl. Akad. Nauk SSSR Ser. Khim., 1989 , vol. 308, # 5 p. 1155 - 1158
反应条件
3-chloro-benzenecarboperoxoic acid in dichloromethane
T=0°C; 0.166667 h;
参考文献
Konosu; Takeda; Tajima; Yasuda; Oida
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 5 p. 1258 - 1265
反应条件
1: Br2; acetic acid
2: anhydrous potassium carbonate / CHCl3 / Heating
View Scheme
参考文献
Ling, Shao; Xin, Zhou; Qing, Zhang; Jian-Bing, Liu; Zhong, Jin; Jian-Xin, Fang
Synthetic Communications, 2007 , vol. 37, # 2 p. 199 - 207
反应条件
1: conc.H2SO4 / methanol / Ambient temperature
2: 72 percent / MeONa / methanol / 0.5 h / Heating
3: 30 percent / TsOH / benzene / 3.5 h / Heating
4: 53 percent / n-butyllithium / hexane; tetrahydrofuran / 0.17 h / -78 °C
5: 82 percent / dimethylformamide / 4 h / 100 °C
6: 93 percent / 2 N HCl / acetone / 2 h / 60 °C / via hydrochloride
7: 23 mg / MCPBA / CH2Cl2 / 0.17 h / 0 °C
View Scheme
参考文献
Konosu; Takeda; Tajima; Yasuda; Oida
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 5 p. 1258 - 1265
